关键词: 结核, 肺/药物疗法, 结核, 抗多种药物性/药物疗法, 治疗结果, 回顾性研究

Abstract: Objective  To explore the treatment outcome and related influencing factors of multidrug-resistant pulmonary tuberculosis (MDR-TB) in Guangzhou. Methods  Logistic regression analysis was adopted to analyze the factors affecting the chemotherapeutic results of 116 MDR-TB patients registered in Guangzhou Chest Hospital and Guangzhou Center for TB Control and Prevention from January 2003 to December 2007. Results  There were 75 male patients accounting for 64.7% and 41 female patients accounting for 35.3% of 116 patients. The age ranged from 20 to 84 years old and the average age was (44.26±17.57) years old. The cure rate of MDR-TB patients was 55.2%（64/116）and the failure rate was 25.0%（29/116）.Eight patients died of TB and 5 patients died of other diseases, the death rate was 11.2%（13/116）.Multivariate logistic regression analysis showed that irregular treatment（OR=13.745；95%CI:3.147-60.034）, irrational chemotherapy regimens（OR=9.897；95%CI:2.528-38.747）and with lung cavitary lesions（OR=10.295；95%CI:2.002-52.949）were risk factors for treatment failure and death of MDR-TB. Conclusion  Based on the drug susceptibility results and the extent of lung cavity,  to developing the reasonable treatment regimens and strengthen the treatment supervision of MDR-TB patients could reduce the treatment failure and mortality of MDR-TB and control the epidemic of MDR-TB.

Key words: Tuberculosis, pulmonary/drug therapy, Tuberculosis, multidrug-resistant/drug therapy, Treatment ontcome, Retrospective studies