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中国防痨杂志 ›› 2005, Vol. 27 ›› Issue (5): 302-304.

• 论著 • 上一篇    下一篇

恶性淋巴瘤误诊结核病27例分析

张炎林;袁保东;杜鹃;胡明;   

  1. 湖北省武汉市肺科医院、武汉市结核病防治所武汉 430030;
  • 出版日期:2005-05-10 发布日期:2005-11-03

The clinical and pathologic analysis of 27 cases malignant lymphoma misdiagnosed as tuberculosis

Zhang Yanlin,Yuan Baodong,Du juan,et al.   

  1. Wuhan City Pulmonary Hospital,Wuhan City Tuberculosis Control Center,Hubei 430030,China
  • Online:2005-05-10 Published:2005-11-03

摘要: 目的 探讨误诊为结核病的淋巴瘤的临床特征和误诊原因。方法 回顾分析1990—2003年27例误诊为结核的恶性淋巴瘤病人的临床特征、影像学特点、病理结果、诊断和治疗。结果 其临床特征无特异性,约8例(29%)无症状,发热19例(70%),咳嗽8例(29%),咯血1例(0.4%),淋巴结肿大22例,其中单一部位6例,多部位16例,其影像学特点是肿块结节样病变10例,弥漫性病变5例,肺门增大11例,胸腔积液10例。误诊淋巴结核6例,误诊肺结核5例,误诊肺结核并淋巴结核10例,误诊肺结核并结核性多浆膜腔积液4例,误诊结核性多浆膜腔积液2例。确诊方式:淋巴结摘除病理活检22例,经纤支镜肺活检2例,经皮肺活检3例。病理结合免疫组化诊断霍奇金病7例,非霍奇金病20例。治疗以放化疗为主,预后差。结论 因二者临床特征相似,易误诊,及时早期获得组织病理标本是早期诊断的关键。

关键词: 淋巴瘤, 结核, 误诊

Abstract: Objective To study the clinical and pathologic characteristics of malignant lymphoma misdiagnosed as tuberculosis and its misdiagnosed reasons.Method The clinical and pathologic manifestations,X-ray features,diagnosis and treatments of 27 diagnosed malignant lymphoma cases misdiagnosed as tuberculosis from 1996 to 2003 were retrospectively analyzed.Results There were no specific clinical characteristics.The most common symptoms were fever(19/27),cough(8/27) and hemoptysis(1/27),8 cases without of symptoms(29%),the enlargement of the lymph nodes were in found in 22 cases.The X-ray showed as bumpnade lesions(10 cases),diffuse lesions(5 cases),hilar lymphadenopathy(11cases),pleural effusion(10 cases).Confirmed diagnosis was made by pathologic and immunohistochemical examinations through lymph node excision(22cases),bronchoscopy(2cases),or percutaneous needle lung biopsy(3cases).and 7 cases were confirmed as Hodkin’s lymphomas and 20 cases without Hodkin’s lymphomas.The main treatment Methods were radiotherapy and chemotherapy.The treatment outcome was poor.Conclusion There were similarities on clinical and pathologic manifestations,X-ray features between malignant lymphoma and tuberculosis.Misdiagnosis was common.Appropriate invasive biopsy procedures were necessary for early diagnosis.

Key words: malignant lymphoma, Tuberculosis, misdiagnosis