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中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (10): 1283-1292.doi: 10.19982/j.issn.1000-6621.20240217

• • 上一篇    

分枝杆菌噬菌体基因组学研究概况

刘珂君1,2, 张海鹏2, 王鹏1,2()   

  1. 1大理大学公共卫生学院,大理 671000
    2云南省地方病防治所,云南省自然疫源性疾病防控技术重点实验室,大理 671000
  • 收稿日期:2024-05-28 出版日期:2024-10-10 发布日期:2024-09-29
  • 通信作者: 王鹏,Email:wp030801@126.com
  • 基金资助:
    云南省高层次卫生健康技术人才培养专项(L-2019001);云南省产业技术创新人才(YNWR-CYJS-2018-012)

Overview of genomic research on Mycobacteriophages

Liu Kejun1,2, Zhang Haipeng2, Wang Peng1,2()   

  1. 1School of Public Health, Dali University, Dali 671000, China
    2Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Institute for Endemic Disease Control and Prevention, Dali 671000, China
  • Received:2024-05-28 Online:2024-10-10 Published:2024-09-29
  • Contact: Wang Peng, Email: wp030801@126.com
  • Supported by:
    Special Fund for Training High-Level Health Technical Personnel of Yunnan Province(L-2019001);Industrial Technology Innovation Talents of Yunnan Province(YNWR-CYJS-2018-012)

摘要:

分枝杆菌感染给全球带来了很大的健康负担,尤其是耐多药结核病(MDR-TB)对公共卫生和卫生安全的威胁,寻找一种有效对抗分枝杆菌感染的方法成为亟待解决的问题。分枝杆菌噬菌体是特异性感染分枝杆菌的病毒,可以通过裂解宿主菌导致其死亡。目前,大量的分枝杆菌噬菌体已被分离和完成全基因组测序,可以帮助我们深入了解噬菌体的遗传多样性和基因组结构,并推动其应用和发展。因此,本文综述了分枝杆菌噬菌体基因组学的一般特征及基因功能与表达,以提供分枝杆菌噬菌体治疗新思路。

关键词: 分枝杆菌感染, 分枝杆菌噬菌体, 基因组学, 基因表达, 综述文献(主题)

Abstract:

Mycobacterial infections represent a significant global health burden, with multidrug-resistant tuberculosis (MDR-TB) posing a critical public health crisis and a serious threat to health security. Identifying effective strategies to combat mycobacterial infections has become an urgent priority. Mycobacteriophages, viruses that specifically target and lyse mycobacteria, offer a promising approach by effectively killing the host bacteria. litating the advancement of mycobacteriophage applications. This review explores the general genomic characteristics, gene functions, and expression patterns of mycobacteriophages, offering a foundation for further research in this field.

Key words: Mycobacterium infections, Mycobacteriophages, Genomics, Gene expression, Review literature as topic

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