血清白蛋白及其衍生生物标志物与慢性阻塞性肺疾病关系研究进展

doi:10.19982/j.issn.1000-6621.20240424

摘要/Abstract

摘要：

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种普遍存在的慢性炎症性肺部疾病,以气流受限和不完全可逆性为特征。COPD的发病机制复杂,包括炎症反应、氧化应激、蛋白酶与抗蛋白酶失衡等。血清白蛋白(albumin, ALB)及其衍生生物标志物作为营养状态和炎症反应的生物指标,对COPD的发病机制、病情评估及预后判断有重要作用。目前,国内外尚无COPD与ALB及其衍生生物标志物的系统性阐述,本文通过综合分析最新的研究成果,增强读者对这些生物标志物在COPD中作用的理解,并揭示其潜在的研究价值。

关键词: 肺疾病, 慢性阻塞性, 血清白蛋白, 生物学标记, 综述文献(主题)

Abstract:

Chronic obstructive pulmonary disease (COPD) is a widespread chronic inflammatory lung disease characterized by airflow limitation and partial irreversibility. The pathogenesis of COPD is complex, involving inflammatory responses, oxidative stress, and proteases anti-proteases imbalance. Serum albumin (ALB) and its derivative biomarkers, as bioindicators of nutritional status and inflammatory response, play an important role in the pathogenesis, disease assessment, and prognosis of COPD. At present, no comprehensive review on the relationship between COPD and serum albumin and its derivative biomarkers has been published. This review synthesizes the latest research findings to deepen our understanding of the role of these biomarkers in COPD and to highlight their potential research value.

Key words: Pulmonary disease, chronic obstructive, Serum albumin, Biological markers, Review literature as topic

中图分类号:

R563

付颖, 熊阳阳, 方思, 李传香, 郭红荣. 血清白蛋白及其衍生生物标志物与慢性阻塞性肺疾病关系研究进展[J]. 中国防痨杂志, 2025, 47(2): 231-236. doi: 10.19982/j.issn.1000-6621.20240424

Fu Ying, Xiong Yangyang, Fang Si, Li Chuanxiang, Guo Hongrong. The research progress on the relationship between serum albumin and its derivative biomarkers and chronic obstructive pulmonary disease[J]. Chinese Journal of Antituberculosis, 2025, 47(2): 231-236. doi: 10.19982/j.issn.1000-6621.20240424

图/表 1

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生物标志物	作用
ALB	影响呼吸肌功能,与住院时间和死亡率相关
AGR	反映感染状态,与住院时间相关
CAR	预测再入院、频繁加重风险和死亡率,评估营养风险
BAR	预测住院病亡率和30d、90d死亡风险
NPAR	与住院病亡率和5年内全因死亡率相关
FAR	反映炎症水平,提示急性加重风险
RAR	与ICU死亡率和预后不良相关
HALP	预测ICU死亡风险和再入院风险
PNI	预测呼吸衰竭和死亡率