布鲁氏菌导致骨组织细胞损害的机制研究进展

doi:10.19982/j.issn.1000-6621.20250531

摘要/Abstract

摘要：

布鲁氏菌病是由布鲁氏菌侵入机体引起的一种人畜共患的自然疫源性传染病,在全球范围内广泛分布。布鲁氏菌病具有显著的全身侵袭性,可累及多个系统,其中骨关节系统损害是最常见的并发症之一。布鲁氏菌导致骨关节系统损害的具体发病机制仍未完全阐明,并且由于早期临床症状及影像学表现不典型,使得临床诊疗面临重大挑战。多数患者明确诊断时病情已进展至晚期阶段,此时骨组织遭受严重破坏,引起灾难性的功能丧失和生活质量急剧下降。因此为提高临床工作者对布鲁氏菌导致骨关节系统损害的认识及重视程度,作者从布鲁氏菌对成骨、破骨和骨细胞的致病机制入手,对布鲁氏菌导致骨关节系统损害的机制进行综述,以期为该病的研究及治疗提供新的思路和方向。

关键词: 布鲁氏菌, 骨和骨组织, 传染病, 感染

Abstract:

Brucellosis is a zoonotic, natural focal infectious disease caused by invasion of Brucella into human body, with a wide distribution globally. It exhibits pronounced systemic invasiveness, affecting multiple systems, among which damage to the osteoarticular (bone and joint) system stands out as one of the most prevalent complications. The precise pathogenic mechanism by which Brucella induces osteoarticular system damage remains incompletely understood. Furthermore, due to the atypical early clinical symptoms and imaging manifestations, its clinical diagnosis and treatment encounter significant challenges. By the time most patients receive a definitive diagnosis, the disease has often already progressed to an advanced stage, characterized by severe destruction of bone tissue, leading to catastrophic functional impairment and a sharp decline in quality of life. To enhance clinical practitioners’ awareness and understanding of Brucella-induced osteoarticular system damage, we reviewed the pathogenic mechanisms of Brucella on osteoblasts, osteoclasts, and bone cells, aiming to provide novel insights and directions for the research and treatment of this disease.

Key words: Brucella, Bone and bones, Communicable diseases, Infection

中图分类号:

赵萌, 阿卜杜萨拉木·阿力木江, 王茜, 张俊, 徐子逸, 廖俊儒, 马创. 布鲁氏菌导致骨组织细胞损害的机制研究进展[J]. 中国防痨杂志, 2026, 48(9): 1428-1435. doi: 10.19982/j.issn.1000-6621.20250531

Zhao Meng, Abdusalam Alimujiang, Wang Xi, Zhang Jun, Xu Ziyi, Liao Junru, Ma Chuang. Research progress on the mechanisms of bone tissue cell damage caused by Brucella[J]. Chinese Journal of Antituberculosis, 2026, 48(9): 1428-1435. doi: 10.19982/j.issn.1000-6621.20250531

图/表 1

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