关键词: 结核, 肺, HIV感染, 获得性免疫缺陷综合征, CD4淋巴细胞计数

Abstract: Objective To investigate the correlation of CD4⁺ T lymphocyte count of HIV-infected individual or AIDS patients and clinical symptoms and signs of TB patients. Methods Seven hundred and thirty-three HIV-infected or AIDS cases registered during July 2010 to June 2012 were selected in Guangxi CDC, Guangxi Longtan Hospital and the Fourth People’s Hospital of Nanning city. Liquid culture and improving neutral roche method were used for mycobacterium culture. The flow cytometry test was used for detecting CD4⁺ T lymphocyte count. The correlation between their CD4⁺ T cell count and TB clinical signs and symptoms was analyzed. Results The positive rate of sputum mycobacterium culture in HIV-infected individual or AIDS patients was 16.1% (118/733). The positive rates of sputum culture in class 1, 2, 3 and 4 of CD4⁺ T lymphocyte count were 12.3% (9/73), 10.3%（6/58）, 17.0%（15/88）and 17.1%（88/514）, respectively. There were no statistically significant difference between different classes of CD4⁺ T lymphocyte count (χ² Linear-by-Linear=2.004, P=0.157).There was a correlation between mycobacterium culture result and CD4⁺ T lymphocyte count in different classes (r=-0.048, P=0.035). The CD4⁺ T lymphocyte count was lower in the cases with cough more than 2 weeks（1.54±0.65）lg than those without cough more than 2 weeks（1.68±0.70）lg (t=-2.621，P=0.009). Conclusion The CD4⁺ T lymphocyte count of HIV-infected individual or AIDS patients has a correlation with the results of sputum mycobacterium culture. The cough in HIV-infected individual or AIDS patients for more than 2 weeks should be paid more attention on the combination of pulmonary tuberculosis.

Key words: Tuberculosis, pulmonary, HIV infections, Acquired immunodeficiency syndrome, CD4 Lymphocyte count