中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系

中国防痨杂志 ›› 2011, Vol. 33 ›› Issue (4): 204-208.

中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系

车南颖¹ 姜世闻² 高铁杰³ 李松¹ 张旭霞¹ 张慧²张治国³ 王黎霞²李传友¹

1.首都医科大学附属北京胸科医院，北京，101149; 2.中国疾病预防控制中心/结核病预防控制中心，北京，102206; 3.北京市昌平区结核病防治所，北京，102200

收稿日期:2010-12-12 出版日期:2011-04-20 发布日期:2012-03-16
通信作者: 李传友 E-mail:lichuanyou6688@hotmail.com；wanglx@chinatb.org
基金资助:
国家科技重大专项“结核病发病模式的研究”(No.2008ZX10003-007)

Relationship between toll-like receptor 2 gene polymorphism and pulmonary tuberculosis in Chinese Han population

Che Nanying¹,Jiang Shiwen²,Gao Tiejie³,Li Song¹,Zhang Xuxia¹,Zhang Hui²,Zhang Zhiguo³,Wang Lixia²,Li Chuanyou¹

1.Beijing Chest Hospital; Capital Medical University; Beijing 101149; China; 2.Center for tuberculosis control and prevention; Chinese center for disease control and prevention; Beijing 102206; 3.Beijing Changping center for tuberculosis control and prevention; Beijing 102200;

Received:2010-12-12 Online:2011-04-20 Published:2012-03-16
Contact: Li Chuanyou E-mail:lichuanyou6688@hotmail.com；wanglx@chinatb.org

摘要/Abstract

摘要： 目的检测中国汉族人群特异TLR2基因多态性，并分析与结核病易感性之间关系。方法在小样本中测序检测TLR2基因中可能存在的基因多态性，再用连接酶特异检测技术在大样本进行SNP分型，并通过统计学方法分析基因多态性与结核病易感性之间相关性。结果共检测到6个基因多态性，它们在结核病患者与健康人之间等位基因、基因型以及单配体型上差异无统计学意义（P>0.05）。结论 TLR2基因多态性并不是中国汉族人群结核病发病的重要危险因素。

关键词: 结核, 肺, Toll样受体2, 多态现象, 遗传, 疾病遗传易感性, 汉族

Abstract: Objective To study the relationship between toll-like receptor 2 (TLR2) gene polymorphisms and susceptibility to pulmonary tuberculosis in Chinese Han population.  Methods TLR2 gene polymorphisms were analyzed by DNA sequencing in a small amount of samples. SNPs in TLR2 gene were detected by ligase detection technique in a large amount of samples. The relationship between TLR2 gene polymorphisms and susceptibility to pulmonary tuberculosis were analyzed by statistic Methods .  Results Six gene polymorphisms were found, but there were no significant differences between pulmonary tuberculosis patients and healthy controls by allelic and genotypic analysis (P>0.05).  Conclusion TLR2 gene polymorphisms are not risk factors for susceptibility to pulmonary TB in Chinese Han population.

Key words: tuberculosis,pulmonary, Toll-like receptor 2, polymorphism genetic, genetic predisposition to disease, Han notionality

中图分类号:

R521

车南颖姜世闻高铁杰李松张旭霞张慧张治国王黎霞李传友. 中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系[J]. 中国防痨杂志, 2011, 33(4): 204-208.

Che Nanying,Jiang Shiwen,Gao Tiejie,Li Song,Zhang Xuxia,Zhang Hui,Zhang Zhiguo,Wang Lixia,Li Chuanyou. Relationship between toll-like receptor 2 gene polymorphism and pulmonary tuberculosis in Chinese Han population[J]. Chinese Journal of Antituberculosis, 2011, 33(4): 204-208.

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