结核病自然史的阶段划分及其诊断的现状与展望

doi:10.3969/j.issn.1000-6621.2021.11.005

摘要/Abstract

摘要：

人体从感染结核分枝杆菌到发病是一个复杂的连续的过程,这一过程被人为地划分成多个阶段。以往的科学研究、诊断检测和药物治疗主要关注潜伏感染和活动性结核病,而结核病的持续高疫情使人们逐渐关注其他的阶段。结核病自然史不同阶段的定义及对每个阶段特征的理解对研发新的诊断技术和制定更合理的干预措施至关重要。笔者就结核分枝杆菌自然史的各个阶段的定义及其特征,以及各阶段诊断的现状与发展方向进行综述,希望能够为研发结核病诊断技术和制定预防干预措施提供思考。

关键词: 结核, 自然史, 诊断, 综述文献(主题)

Abstract:

From Mycobacterium tuberculosis infection to active disease, it is a complex continuous process that has been artificially separated into many stages. The focus of past studies, diagnostic tests, and pharmacological therapy are mainly on latent infection or active disease. The continuing high epidemic of tuberculosis has led to a gradual focus on other stages. Understanding the definition and characteristics of the different stages in the natural history of tuberculosis is essential for developing new diagnostic techniques and developing more rational interventions. This article provided a review of the definitions and characteristics of the various stages in the natural history of tuberculosis and the current status and prospect of its diagnosis, with the hope to aid in the development of early diagnostic tools and tuberculosis prevention strategies.

Key words: Tuberculosis, Natural history, Diagnosis, Review literature as topic

李蒙, 高谦. 结核病自然史的阶段划分及其诊断的现状与展望[J]. 中国防痨杂志, 2021, 43(11): 1125-1131. doi: 10.3969/j.issn.1000-6621.2021.11.005

LI Meng, GAO Qian. Stages in the natural history of tuberculosis and the current status and prospect of diagnosis[J]. Chinese Journal of Antituberculosis, 2021, 43(11): 1125-1131. doi: 10.3969/j.issn.1000-6621.2021.11.005

图/表 1

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