关键词: 结核, 抗多种药物性/药物疗法, 乙酰胺类, 恶唑烷酮类, 评价研究

Abstract: Objective To evaluate the efficacy and safety of linezolid for treating multidrug resistant tuberculosis（MDR-TB）. Methods Cochrane Controlled Trials database, Pubmed, Embase, CBM, CNKI, Wanfang Date and other electronic databases were searched. Clinical studies matched the inclusion criteria would be analysed statistically. Results A total of five clinical studies met the inclusion criteria in seven countries. The Results showed that the mean proportion of patients achieving treatment success was 82% (95% CI 73％—89%); the mean proportion of patients whose outcome were treatment failure,default and death were 2%, 5% and 11%,respectively. The incidence rate of adverse events in hematopoietic system and neurotoxicity and gastrointestinal system were 32%, 25%, 6%, respectively.  Conclusion Linezolid against MDR-TB has a good efficacy, but the incidence of adverse events is higher.

Key words: tuberculosis,multidrug-resistant/drug therapy, acetamides, oxazolidinones, evaluation studies