关键词: 结核, 肺/药物疗法, 治疗结果, 包头市

Abstract: Objective To evaluate the effect of supervision chemotherapy of smear positive tuberculosis patients in Baotou and analyze factors affecting the chemotherapy effect. Methods 1993 cases of tuberculosis patients with positive sputum smear examined in the Disease Prevention and Control Center of Baotou from January 2005 till December 2009 were selected and subjected to regression analysis in the following 13 categories including sex, age, vocation, household registration, hospital visit style, diagnosis classification, severe tuberculosis, treatment grouping, treatment plan, with or without cavity, with or without miliary tuberculosis, administrating manner, prognosis. P<0.05 is considered statistically significant. Results Through single factor analysis, it has been found that the Odd Ratio (OR) and 95% Confidence Intervals (95% CI) for age factor are 0.981 and 0.972～0.990 respectively (with P value equal to 0.000), the OR and 95% CI for vocation factor are 0.385 and 0.190～0.777 respectively (with P value equal to 0.008), the OR and 95% CI for household registration factor are 0.235 and 0.144～0.384 respectively (with P value equal to 0.000), the OR and 95% CI for administrating manner factor are 0.019 and 0.008～0.047 respectively (with P value equal to 0.000), indicating that these four factors of age, vocation, household registration and administrating manner are factors affecting the effect of supervision chemotherapy of smear positive tuberculosis patients. Through multiple factor analysis, our data indicate that age, vocation, household registration, administrating manner, treatment plan, and miliary tuberculosis are factors affecting the effect of supervision chemotherapy. Among these factors, age (with OR of 0.989 and P of 0.037), vocation (with OR of 2.250 and P of 0.014) and miliary tuberculosis (with OR of 0.332 and P of 0.004) are risk factors while household registration (with OR of 0.276 and P of 0.003), administrating manner (with OR of 0.010 and P of 0.000), and treatment plan (with OR of 10.719 and P of 0.036) are protective factors. Conclusion Our analysis indicates that extra attention ought to be paid to the following pulmonary tuberculosis patients including medium-elderly men, migrant workers, and miliary tuberculosis patients. Administrating mode of whole course supervision system and highly effective chemotherapy plan ought to be adopted to raise cure rate and lessen recurrence rate.

Key words: Tuberculosis,pulmonary/drug therapy, Treatment outcome, Baotou