CRISPR-Cas系统在结核分枝杆菌研究中的应用进展

doi:10.3969/j.issn.1000-6621.2021.12.018

摘要/Abstract

摘要：

成簇的规律间隔短回文重复序列(clustered regularly interspaced short palindromic repeats,CRISPR)和他们相关的蛋白(Cas)组成了一个新的分布于结核分枝杆菌(MTB)的获得性免疫防御系统。此外,CRISPR-Cas系统与MTB的毒力、耐药以及定向基因编辑方面可能存在重要的关系。笔者主要通过对CRISPR-Cas系统在MTB的免疫作用及其相关研究进展进行综述,以期为进一步研究MTB致病性和抗结核治疗提供一种新思路。

关键词: 分枝杆菌,结核, CRISPR-Cas系统, 抗药性, 转录

Abstract:

Clustered regularly interspaced short palindromic repeats (CRISPR) and their related proteins (Cas) form a new acquired immune defense system distributed in Mycobacterium tuberculosis (MTB). In addition, CRISPR-Cas system may have an important relationship with the virulence, drug resistance and targeted gene editing of MTB. This paper reviews the immune function of CRISPR-Cas system in MTB and its related research progress, in order to provide a new idea for further study of MTB pathogenicity and anti-tuberculosis treatment.

Key words: Mycobacterium tuberculosis, CRISPR-Cas system, Drug resistance, Transcription

杨瑞芳, 李传友. CRISPR-Cas系统在结核分枝杆菌研究中的应用进展[J]. 中国防痨杂志, 2021, 43(12): 1332-1335. doi: 10.3969/j.issn.1000-6621.2021.12.018

YANG Rui-fang, LI Chuan-you. Research progress of relationship between CRISPR-Cas system and Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2021, 43(12): 1332-1335. doi: 10.3969/j.issn.1000-6621.2021.12.018

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