结核病的代谢组学研究进展

doi:10.3969/j.issn.1000-6621.2018.11.015

摘要/Abstract

摘要：

WHO提出2035年要在全球终止结核病流行。要达到这一目标,对结核分枝杆菌耐药性产生机制、新型结核诊断标志物寻找、新型抗结核药物开发等方面的研究必需要有新突破。代谢组学是一种研究机体内源性代谢改变的新兴组学技术。相比于其他组学研究面临的基因复杂性、转录后修饰等问题,代谢组学能够直接全面反映机体内源性代谢信息改变,并通过多元统计分析获得生物体特征代谢标记,为疾病的预防、诊断、治疗、预后等提供指导。目前,代谢组学已被广泛应用于结核病研究,在结核病原学、结核病诊断与治疗等方面都取得了诸多成果。笔者对近年来代谢组学在结核病研究中的进展进行综述。

关键词: 结核, 代谢组学, 病原学, 诊断与治疗, 预后

Abstract:

World Health Organization (WHO) has proposed terminating tuberculosis epidemic globally by 2035.To achieve this goal, new breakthroughs are urgently needed through researches on the mechanism of drug resistance development in Mycobacterium tuberculosis, the search for new tuberculosis diagnostic markers, and the development of new anti-tuberculosis drugs. Metabolomics is an emerging omics technique for studying endogenous metabolic changes in the body. Compared with the issues, such as genetic complexity and post-transcriptional modification, etc., which are faced by other omics researches, metabolomics may directly reflect the changes in the body’s endogenous metabolic information, obtain the metabolic markers of the organisms for disease prevention through multivariate statistical analysis and can provide guidance on the diagnosis, treatment, prognosis of disease. At present, metabolomics has been widely applied in the research of tuberculosis and achievements have been made in terms of the diagnosis and treatment of tuberculosis. The recent progress of metabolomics in tuberculosis research is summarized in this paper.

Key words: Tuberculosis, Metabolomics, Etiology, Diagnosis and treatment, Prognosis

韦金涛,李华,邱恩明. 结核病的代谢组学研究进展[J]. 中国防痨杂志, 2018, 40(11): 1226-1230. doi: 10.3969/j.issn.1000-6621.2018.11.015

WEI Jin-tao,LI Hua,QIU En-ming.. Progress in metabolomics research on tuberculosis[J]. Chinese Journal of Antituberculosis, 2018, 40(11): 1226-1230. doi: 10.3969/j.issn.1000-6621.2018.11.015

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