结核分枝杆菌外泌体的研究进展

doi:10.3969/j.issn.1000-6621.2018.10.018

摘要/Abstract

摘要：

自1983年外泌体被发现,有关外泌体的研究在不断深入,其功能也不断被发现,如作为分子标记物诊断疾病的发生、影响机体免疫功能等。细菌中同样存在外泌体,其可以影响宿主的免疫,当细菌感染宿主后,宿主所产生的外泌体对宿主的免疫也起着十分重要的作用。作者对结核分枝杆菌外泌体功能的研究进行了综述,并以分枝杆菌为代表,对细菌的外泌体功能结合文献进行了阐述。

关键词: 分枝杆菌, 结核, 分枝杆菌属, 外泌体, 生物学标记, 生物医学研究, 功能

Abstract:

Since exosomes have been discovered in 1983, research on exosomes has been deepening, and their functions have been discovered constantly, such as diagnosing the occurrence of diseases as molecular markers and affecting the body’s immune function. Exosomes also exist in bacteria, which can affect the host immunity. When bacteria infect the host, the exosomes produced by the host also play a very important role in the host immunity. The function of exosomes of Mycobacterium tuberculosis is reviewed. In addition, the function of bacteria exosomes, represented by mycobacterium, is described.

Key words: Mycobacterium tuberculosis, Mycobacterium, Exosomes, Biological markers, Biomedical research, Functions

王鑫洋,付英梅,赵雁林,张凤民. 结核分枝杆菌外泌体的研究进展[J]. 中国防痨杂志, 2018, 40(10): 1129-1133. doi: 10.3969/j.issn.1000-6621.2018.10.018

Xin-yang WANG,Ying-me FU,Yan-lin ZHAO,Feng-min ZHANG. Research progress of Mycobacterium tuberculosis exosome[J]. Chinese Journal of Antituberculosis, 2018, 40(10): 1129-1133. doi: 10.3969/j.issn.1000-6621.2018.10.018

图/表 2

参考文献 42

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编号	蛋白名称	理论 Mw/pI	观察Mw/pI	序列覆盖 (%)	相配多肽 (个)	得分	倍数变化
P60709	肌动蛋白,细胞质1	42.0/5.29	40.7/5.13	24	7	100	1.78
P60709	肌动蛋白,细胞质1	42.0/5.29	40.6/5.10	22	8	100	2.31
P62873	鸟嘌呤核苷酸结合蛋白G (I)/G(S)/G(T)亚基β-1	38.1/5.60	36.8/5.70	8	2	56	1.97
P23528	钴纤维蛋白-1	18.7/8.22	12.01/8.66	34	5	167	1.92
P62937	肽基脯氨酰顺反异构酶A	18.2/7.68	11.53/8.31	50	10	136	2.13