脊柱结核动物模型建立的研究进展

doi:10.3969/j.issn.1000-6621.2018.10.019

摘要/Abstract

摘要：

骨与关节结核是较为多见的肺外结核。在骨与关节结核患者中,超过50%的患者发病部位位于脊柱。近些年,国内外学者对于脊柱结核的药物缓释、手术方式、内置物等治疗的研究内容逐渐增多,这些研究主要是建立类似于人体脊柱结核病变的动物模型。作者对于近年来脊柱结核动物模型建立的重要内容进行综述,以期使相关研究者了解脊柱结核动物模型建立的特点。

关键词: 结核, 脊柱, 疾病模型, 动物, 研究, 综述

Abstract:

Bone and joint tuberculosis is one of the most common extrapulmonary tuberculosis. In more than 50% of the patients with bone and joint tuberculosis, infection is located in the spinal column. In recent years, scholars at home and abroad have gradually increased the study of drug release, surgical methods, and internal substances for spinal tuberculosis. These studies are mainly based on the establishment of animal models similar to human spinal tuberculosis. The authors reviewed the important content of the animal model of spinal tuberculosis in recent years, in order to make the relevant researchers understand the characteristics of the establishment of the animal model of spinal tuberculosis.

Key words: Tuberculosis, spinal, Disease models, animal, Research, Review

蔡则成,马赫,戈朝晖. 脊柱结核动物模型建立的研究进展[J]. 中国防痨杂志, 2018, 40(10): 1134-1137. doi: 10.3969/j.issn.1000-6621.2018.10.019

Ze-cheng CAI,He MA,Zhao-hui GE. The progress of establishing animal model of spinal tuberculosis[J]. Chinese Journal of Antituberculosis, 2018, 40(10): 1134-1137. doi: 10.3969/j.issn.1000-6621.2018.10.019

参考文献 37

[1]	World Health Organization . Global tuberculosis report 2017. Geneva: World Health Organization, 2017.
[2]	Chen ST, Zhao LP, Dong WJ , et al. The clinical features and bacteriological characterizations of bone and joint tuberculosis in China. Sci Rep, 2015,5:11084.
[3]	Huang D, Li D, Wang T , et al. Isoniazid conjugated poly (lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy. Biomaterials, 2015,52:417-425.
[4]	Liu P, Fu Z, Jiang J , et al. Determination of isoniazid concentration in rabbit vertebrae by isotope tracing technique in conjunction with HPLC. Biomed Chromatogr, 2013,27(9):1150-1156. doi: 10.1002/bmc.2920
[5]	Carrillo C, Wigdorovitz A, Trono K , et al. Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants. Viral Immunol, 2001,14(1):49-57.
[6]	Ghodbane R, Raoult D, Drancourt M . Dramatic reduction of culture time of Mycobacterium tuberculosis. Sci Rep, 2014,4:4236.
[7]	林旭 . 缓释利福平微球释药性质及兔脊柱结核模型建立的初步实验研究. 成都:四川大学, 2006. doi: 10.7666/d.y995200 URL
[8]	苏明权, 张建芳, 苏哲 , 等. 一种新型结核杆菌快速培养促生长剂的研制. 中国人兽共患病学报, 2006,22(11):1062-1064. doi: 10.3969/j.issn.1002-2694.2006.11.015 URL
[9]	Guo XH, Bai Z, Qiang B , et al. Roles of monocyte chemotactic protein 1 and nuclear factor-κB in immune response to spinal tuberculosis in a New Zealand white rabbit model. Braz J Med Biol Res, 2017,50(3):e5625.
[10]	乔永杰, 李松凯, 甄平 , 等. 不同浓度结核菌建立兔脊柱结核模型的对比研究. 中国矫形外科杂志, 2017,25(5):459-465.
[11]	陈领, 贾赤宇 . 结核性创面动物模型研究进展. 中华烧伤杂志, 2015,31(6):436-438. doi: 10.3760/cma.j.issn.1009-2587.2015.06.012 URL
[12]	Wang XW, Liu JJ, Wu QN , et al. The in vitro and in vivo effects of microRNA-133a on intervertebral disc destruction by targeting MMP9 in spinal tuberculosis. Life Sci, 2017,188:198-205.
[13]	Smith DW, Harding GE . Animal model of human disease. Pulmonary tuberculosis. Animal model: Experimental airborne tuberculosis in the guinea pig. Am J Pathol, 1977,89(1):273-276.
[14]	Orme IM, Ordway DJ . Mouse and guinea pig models of tuberculosis. Microbiol Spectr, 2016,4(4). doi: 10.1128/microbiolspec.TBTB2-0002-2015 URL pmid: 27726797
[15]	Dharmadhikari AS, Nardell EA . What animal models teach humans about tuberculosis. Am J Respir Cell Mol Biol, 2008,39(5):503-508.
[16]	Dutta NK, Illei PB, Jain SK , et al. Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice. Am J Pathol, 2014,184(7):2045-2055.
[17]	Bai X, Shang S, Henao-Tamayo M , et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A, 2015,112(16):5111-5116.
[18]	Jasenosky LD, Scriba TJ, Hanekom WA , et al. T cells and adaptive immunity to Mycobacterium tuberculosis in humans. Immunol Rev, 2015,264(1):74-87.
[19]	Acosta A, Norazmi MN, Hernandez-Pando R , et al. The importance of animal models in tuberculosis vaccine development. Malays J Med Sci, 2011,18(4):5-12. URL pmid: 22589668
[20]	高琪乐, 张宏其, 郭超峰 , 等. 小鼠脊柱结核模型的构建及椎体骨密度改变的初步研究. 中国矫形外科杂志, 2018,26(2):155-158.
[21]	Subbian S, Tsenova L , O’Brien P, et al. Spontaneous latency in a rabbit model of pulmonary tuberculosis. Am J Pathol, 2012,181(5):1711-1724.
[22]	Manabe YC, Dannenberg AM Jr, Tyagi SK , et al. Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun, 2003,71(10):6004-6011.
[23]	Dannenberg AM Jr . Perspectives on clinical and preclinical testing of new tuberculosis vaccines. Clin Microbiol Rev, 2010,23(4):781-794. doi: 10.1128/CMR.00005-10 URL pmid: 2952977
[24]	陈振, 吴鹏, 马荣 , 等. 构建新西兰兔脊柱结核模型的实验研究. 宁夏医科大学学报, 2015,37(10):216-223. doi: 10.16050/j.cnki.issn1674-6309.2015.10.003 URL
[25]	Flynn JL, Gideon HP, Mattila JT , et al. Immunology studies in non-human primate models of tuberculosis. Immunol Rev, 2015,264(1):60-73. doi: 10.1111/imr.12258 URL pmid: 25703552
[26]	Peña JC, Ho WZ . Non-human primate models of tuberculosis. Microbiol Spectr, 2016,4(4). doi: 10.1128/microbiolspec.TBTB2-0007-2016 URL pmid: 27726820
[27]	Sharpe S, White A, Gleeson F , et al. Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques. Tuberculosis (Edinb), 2016,96:1-12.
[28]	Orr MT, Fox CB, Baldwin SL , et al. Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis. J Control Release, 2013,172(1):190-200.
[29]	Lindberg L . A method for producing experimental skeletal tuberculosis in bone marrow necrosis in the guineapig. Acta Pathol Microbiol Scand, 1968,72(4):575-585.
[30]	吴启秋, 段连山, 梁桂芳 , 等. 兔膝关节结核模型的建立及其应用. 结核病与胸部肿瘤, 2002, ( 3):174-176.
[31]	Liu P, Jiang H, Li S , et al. Determination of anti-tuberculosis drug concentration and distribution from sustained release microspheres in the vertebrae of a spinal tuberculosis rabbit model. J Orthop Res, 2017,35(1):200-208.
[32]	Geng G, Wang Q, Shi J , et al. Establishment of a New Zea-land rabbit model of spinal tuberculosis. J Spinal Disord Tech, 2015,28(3):E140-145. doi: 10.1097/BSD.0000000000000191 URL pmid: 25325713
[33]	王非, 瞿东滨, 金大地 . 侧方入路显露兔腰椎间盘及椎间盘内的注射方法. 中华实验外科杂志, 2003,20(3):204. doi: 10.3760/j.issn:1001-9030.2003.03.039 URL
[34]	王云玲, 刘莹, 王红 , 等. 建立新西兰白兔脊柱结核的两种方法比较研究. 新疆医学, 2012,42(6):1-4. doi: 10.3969/j.issn.1001-5183.2012.06.001 URL
[35]	Geng G, Wang Q, Wang Z , et al. Comparative study of the spinal tuberculosis model with the New Zealand rabbit. Chin J Orthop, 2014,34(2):216-223. doi: 10.3760/cma.j.issn.0253-2352.2014.02.019 URL
[36]	Liu XC, Jia WX, Wang H , et al. Applications of diffusion-weighted mr imaging in rabbits mode of spinal tuberculosis. Chin Comp Med, 2014,20(2):182-186.
[37]	Liu X, Jia W, Wang H , et al. Establishment of a rabbit model of spinal tuberculosis using Mycobacterium tuberculosis strain H37Rv. Jpn J Infect Dis, 2015,68(2):89-97.