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中国防痨杂志 ›› 2018, Vol. 40 ›› Issue (6): 604-608.doi: 10.3969/j.issn.1000-6621.2018.06.011

• 论著 • 上一篇    下一篇



  1. 563003 遵义医学院附属医院呼吸二科
  • 收稿日期:2018-03-16 出版日期:2018-06-20 发布日期:2018-07-24
  • 基金资助:

Analysis of the drug-resistant status of 870 patients with pulmonary tuberculosis from 2013 to 2016

Yu-qin LI,Min XIANG,Ling CHNE(),Jian-yong ZHANG,Yue-juan HE,Na-na. LI   

  1. The Second Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003,China
  • Received:2018-03-16 Online:2018-06-20 Published:2018-07-24

摘要: 目的





870例肺结核患者中,初治患者611例,复治患者259例;患者总耐药率为26.6%(231/870),耐多药率为12.1%(105/870)。初治患者的总耐药率为16.4%(100/611),复治患者的总耐药率为50.6%(131/259),差异有统计学意义(χ 2=56.74,P<0.01)。初治患者的单耐药率为9.7%(59/611),复治患者的单耐药率为10.0%(26/259),差异无统计学意义(χ 2=0.03,P=0.862)。初治患者的多耐药率为3.1%(19/611),复治患者的多耐药率为8.5%(22/259),差异有统计学意义(χ 2=11.74,P<0.01)。初治患者的耐多药率为3.6%(22/611),复治患者的耐多药率为32.0%(83/259),差异有统计学意义(χ 2=138.69,P<0.01)。



关键词: 结核, 肺, 结核, 抗多种药物性, 小地区分析, 对比研究

Abstract: Objective

To understand the situation of drug resistant tuberculosis in the Affiliated Hospital of Zunyi Medical College in order to provide scientific evidence for the drug resistant tuberculosis prevention and control strategies.


A total of 870 Mycobacterium tuberculosis isolates composed of sputum and bronchoalveolar lavage fluid were collected from patients with pulmonary tuberculosis (PTB) in the Affiliated Hospital of Zunyi Medical College during the years of 2013 to 2016. Drug sensitivity tests against 4 anti-TB drugs (rifampicin, isoniazid, ethambutol and streptomycin) were performed using the Roche culture and proportion method. The demographic and drug resistance information were collected.


Among the 870 cases, 611 cases were new patients and 259 cases were previously treated patients. The total rates of drug resistant and multidrug-resistant (MDR) were 26.6% (231/870) and 12.1% (105/870),respectively. The total drug resistant rates of new and previously treated patients were 16.4% (100/611) and 50.6% (131/259),respectively, and the difference was statistically significant (χ 2=56.74,P<0.01). The single drug resistance rates of new and previously treated patients were 9.7% (59/611) and 10.0% (26/259), respectively, and the difference was not statistically significant (χ 2=0.03, P=0.862). The polyresistance rates of new and previously treated patients were 3.1% (19/611) and 8.5% (22/259),respectively. The difference was statistically significant (χ 2=11.74, P<0.01). The MDR rates of new and previously treated patients were 3.6% (22/611) and 32.0% (83/259), respectively. And the difference was statistically significant (χ 2=138.69, P<0.01).


Retreatment would increase the risk of TB’s resis-tance to drugs. Consequently, there is a urgent call for the improvement of drug resistance screening and standar-dized treatment for retreated PTB patients.

Key words: Tuberculosis, pulmonary, Tuberculosis, multidrug-resistant, Small-area analysis, Com-parative study