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中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (12): 1131-1133.doi: 10.19982/j.issn.1000-6621.20230379

• 专题笔谈 • 上一篇    下一篇

重视无痰患者肺结核诊断 发掘舌拭子替代潜能

董裕, 逄宇()   

  1. 首都医科大学附属北京胸科医院细菌免疫研究室,北京 101149
  • 收稿日期:2023-10-19 出版日期:2023-12-10 发布日期:2023-11-27
  • 通信作者: 逄宇,Email:pangyupound@163.com
  • 基金资助:
    北京市高层次公共卫生技术人才建设项目(Discipline Leader-02-26)

Focusing on the diagnosis of pulmonary tuberculosis in sputum-free patients and exploring the potential of tongue swab substitution

Dong Yu, Pang Yu()   

  1. Department of Bacteriology and Immunology,Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
  • Received:2023-10-19 Online:2023-12-10 Published:2023-11-27
  • Contact: Pang Yu, Email: pangyupound@163.com
  • Supported by:
    Beijing High-level Public Health Technical Personnel Construction Project(Discipline Leader-02-26)

摘要:

结核病是全球面临的健康威胁。肺结核是结核病的主要形式,痰液是首选的诊断标本,基于痰液的细菌学或分子生物学检查已成为金标准,但这增加了无痰患者的诊断难度。支气管肺泡灌洗液、胃液等非痰标本可用于肺结核诊断,但在采集过程中存在困难和不便。舌拭子作为一种采集简便、快捷且生物安全风险较小的标本,可能成为理想的痰液替代标本类型,或用于辅助肺结核诊断的新手段。本文中,笔者强调应重视对无痰肺结核患者的诊断,并展望了舌拭子在肺结核诊断中的应用前景。

关键词: 结核,肺, 痰, 舌拭子, 诊断

Abstract:

Tuberculosis is a global health threat. Pulmonary tuberculosis is the main form of tuberculosis, and sputum is the preferred diagnostic specimen. The bacteriological or molecular biological tests for sputum have become the gold standard, however, the difficulty of diagnosis in sputum-free patients is increasing. Although bronchial lavage fluid and gastric fluid can be used in the diagnosis of pulmonary tuberculosis, there are difficulties and inconveniences in the collection process. Tongue swab, as a simple and rapid specimen with low biosafety risk, may be an ideal replacement type of sputum specimen or a new means to assist in the diagnosis of tuberculosis. In this paper, the author emphasizes the importance of the diagnosis of patients with sputum-free pulmonary tuberculosis, and looks forward to the application of tongue swab in the diagnosis of pulmonary tuberculosis.

Key words: Tuberculosis, pulmonary, Sputum, Tongue swab, Diagnosis

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