Table of Content

10 April 2000, Volume 22 Issue 4

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The evaluation of conducting the World-Bank loan tuberculosis control project in Shandong

WANG Shi-chang.

Chinese Journal of Antituberculosis. 2000, 22(4):  179-181. 

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Objective To analyze the effect of conducting tuberculosis control loan project by the World-Bank.Methods The tuberculosis control project seasonal reports(1992～1998)were collected by the provincial tuberculosis control project office.Results From 1992 to 1998,the new register rate of newly detected smear positive cases increased from 3.2 to 16.1 per hundred thousand;the cure rate is from 87.8% to 96.7%;the retreatment cases rate is from 77.5% to 94.6%;the ICT(impact of case-finding and treatment of TB control policies)increased from 10.8% to 88.1%.Conclusion Conducting the World-Bank loan tuberculosis control project,has made period progress and acquired viable experience,which is consequently promoting the tuberculosis control work in Shandong province.

The analysis on situation of convergence case-management of suspicious TB cases on general hospital of Shenzhen

TAN Wei-guo,YANG Ying-zhou.

Chinese Journal of Antituberculosis. 2000, 22(4):  182-184. 

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Objective To investigate the situation of convergence case-management of TB in general hospital,to possess the condition of the transferring TB patients and take some measures to enhancing the cases finding level of TB patients. Methods Sampling four municipal hospitals,examine the data of department concerned. Results There are situation fail to diagnosis for TB patients and transfer patients to anti-tuberculosis organs unsuccessfully.Conclusion Take some effective measures to enhance the transferring rate of TB patients successfully.

Analysis of tuberculosis surveillance of Yin county during the period 1994～1998

ZHANG Zhi-peng.

Chinese Journal of Antituberculosis. 2000, 22(4):  185-187. 

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Objective To evaluate TB surveillance of Yin county.Methods To implement TB surveillance according to National Tuberculsosis Program.Results The rates of new registration and new cases registration of smear patients were increased year and year,from 39.39/100000 and 12.61/100000 to 43.79/100000 and 16.11/100000,the new cases negqative sputum conversion rate was 94.8%,the cure rate was 92.5%.By the end of 1998,the ratio of new cases registration of smear patiens and new cases registration(P/I) was 0.48.The mortality was 0.14/100000,putting in order the 18 of all diseases.Conclusion As Strengthening and Promoting TB Control Project was implemented in our county,the finding of infectious cases and the cure rate were improved year by year,the infectious sources were effectually control.But how to improved the clinical consultation rate was vital matter of immediate urgency for us.

Clinical analysis of 95 cases inpatients with pulmonary tuberculosis in the senility

GE Qi-ping,KONG Zhong-shun,BU Jian-ling,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  188-191. 

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Objective To investigate clinical features,proper treatment and management Methods of pulmonary tuberculosis in the senility.Methods A comparison of clinical features,treatment,effect and compliance in cases of pulmonary tuberculosis among 95 senilities(≥80 years) and 80 old patients(60～80 years) was performed.Results (1)Complication of circulatory diseases,innutrition and the number of patients who had more than 3 varieties of complications were larger in group Ⅰthan in group Ⅱ.(2)Cavitary cases of new cases in group Ⅰ were less than that of group Ⅱ(P<0.05).(3)The positive rate of sputum was lower in group Ⅰthan that of groupⅡ(P<0.05) and the effect of treatment were no significantly differences from group Ⅱ(P>0.05).(4)The improvement of X-ray was no significantly difference between three drugs and four drugs(P>0.05),but the side effect with four drugs was significantly higher than with three drugs(P<0.05). Conclusion (1)It is necessary to pay more attention to the senility with pulmonary tuberculosis to avoid delaying diagnosis and trentment.(2)The treatment to senility with pulmonary tuberculosis need proper doses and three drugs project is the best.(3)The effect was satisfied if they received regular treatment both in group Ⅰ and Ⅱ.

The effect of reducing incidence of TB by prophylactic chemotherapy in patients with coal-pneumoconiasis

LIU Su-qin,REN Jian-jun,YANG Huai,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  192-193. 

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Objective To observe the effect of reducing incidence of TB by prophylactic chemotherapy in cases with coal-pneumoconiasis.Methods 269 cases with stage Ⅰ,Ⅱ of coal-pneumoconiasis were devided to 3 groups and to take INH,RFP and placebo respectively for 3～6 months.Results Through after 5 years observation showed the incidence of TB was reduced signifficanly in the group A and group B (take INH or RFP) than The control group(P<0.01).Conclusion The prophylactic chemotherapy(INH,RFP) will reducing the incidence of TB in patients with coal-pneumoconiasis effectively.

Applied value of tuberculin protein polypeptide and microwaves irradiation in detective of active tuberculosis

XIAO Peng-nian,MO Liu-qin,YANG Yi-feng.

Chinese Journal of Antituberculosis. 2000, 22(4):  194-196. 

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Objective To evaluate the diagnostic value of tuberculin protein polypeptide (TPP) and microwaves irradiation in detective of active tuberculosis.Methods Tuberculin protein polypeptide was drawed from culture medum of M.Tuberculosis H₃₇ Rv,was used microwaves-enzyme linked immunosorbent assay,to determine the titer of serum antibody against TPP in active tuberculosis.Results It was found that the tests were positive(≥1：80)in 114 of 126 active tuberculosis cases and in 10 of 76 healthy individuals.The sensitivity was 90.4% and the specificity was 86.8%.Besides,compared with the conventional-enzyme linked immunosorbent assay,the consumptive time of microwaves-enzyme linked immunosorbent assay was reduced considerably,but gain a consistent conclusion.Conclusion The antigen of TPP was proved to be better in sensitivity and specificity.Microwaves-enzyme linked immunosorbent assay can substitute conventional-enzyme linked immunosorbent assay.

The value of serum anti-mycobacterium tuberculosis antibody in the curative effect of pulmonary tuberculosis

LI Tong-xia,CHEN Su-min,XIN Shu-qin.

Chinese Journal of Antituberculosis. 2000, 22(4):  197-198. 

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Objective To study the relationship between anti-mycobacterium tuberculosis antibody in differential stage of pulmonary tuberculosis and the practical value of curative effect of pulmonary tuberculosis.Methods Level of serum anti-mycobacterium tuberculosis antibody were measured in the progressive stage,absorptive resolving stage and stable stage.Results The absorptive,resolving and stable stage of anti-mycobacterium tuberculosis which antibody positive rate was 27.5% and 19.5% respectively,compare with significance difference(P<0.01 ).The negative rate converted of antibody tuberculosis was 75.5%.Conclusion There is high practical value of serum anti-mycobacterium tuberculosis antibody level in the curative effect of pulmonary tuberculosis.

Clinical research of cortiadrenal function in patients with multi-drug resistant pulmonary tuberculosis

XIAO Zhi-jian,CUI Xiu-qin,GUO Yue-peng,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  199-200. 

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Objective To study the change of cortiadrenal function in patient with multi-drug resistant pulmonary tuberculosis.Methods The serum cortisols of 56 patients with multi-drug resistant pulmonary tuberculosis were measured by radiation immunity analysis (RIA),and compared with that of the group of non-drug resistant pulmonary tuberculosis and the normal control group.Results The serum cortisol level of the studied group was significantly higher than the others,there were 842±168(8AM) and 624±62(4PM) positive.Conclusion The cortiadrenal function of the studied group was stronger obviously than normal,but the rhythm of their cortisol excretion was normal.

Analysis on report of tuberculosis after classified to noticeable infectious disease

WANG Lin,GAO San-you,SONG Huai-zhou.

Chinese Journal of Antituberculosis. 2000, 22(4):  201-203. 

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Objective To reveal the problem in report of tuberculosis after classified to grade Ⅱ of noticeable infectious disease.Methods To compare the report of noticeable infctious disease with the register of pulmonary tuberculosis by Microsoft Excel.Results The report numbers were increasing year by year and nearing the register numbers of tuberculosis in Henan Tuberculosis Control Institute.But the underreporting was still aserious problem.There were many troubles in classification,report,management of tuberculosis.Conclusion It was necessary to recognize the importance of tuberculosis report.The report and management should be strengthen more.The checking scheme must be set up.It was possible to resolve the problem in time.

A Mycobacterium marinum strain isolated from the skin lesions of swimming pool granuloma

ZHAO Ting,ZHANG Jian-zhong,DING Bei-chuan,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  204-205. 

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Objective A strain of Mycobacterium marinum was isolated from the skin lesions of swimming pool granuloma.Methods The skin specimen was decontaminated with 2% NaOH,and inoculated to 4 acidity Lowenstien-Jenson cultures.Two cultures were incubated at 28℃,and the other two were at 37℃.The drug sensitivity of the strain were determined by absolute concentration method.The examinations of identification for the strain were performed by routine method described in Bergey’s manual.Results The growth of the strain was markedly better at 28℃ than was at 37℃.The strain was resistance to INH and SM,but was sensitive to RFP and EM.The strain characterized by production of yellow pigment after illumination and by thermostable catalase reaction.The reaction of reduction of nitrate was negative.Conclusion The strain isolated from skin tissue was identified to be M.marinum.

Identification of post-injection outbreak of M.fortuitum by 16S-23S rDNA spacer sequences

ZHANG Ling-xia,ZHUANG Yu-hui,CHI Ying-fan,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  206-208. 

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Objective To determine the pathogen of the post-injection infection outbreak in Nanping at gene level with molecular biological technique and to establish a rapid identification method of M.fortuitum by PCR/RFLP and DNA probe technique.Methods A single pair of prime and oligonucleotide probe of M.fortuitum were designed,according to the sequence of mycobacterium of 16S-23S rDNA spacer sequences.29 clinical strains were amplified by PCR,then dot-blot hybridization and RFLP of PCR products were made.Results 470bp fragment were produced by PCR of 29 clinical strains,three fragment were produced by Hae Ⅲ,MSP Ⅰ digest of PCR products respectively.The probe only hybridized with M.fortuium and 29 clinical strains.Conclusion The Results showed that the pathogen of infection outbreak were M.fortuitum.The 16S-23S rDNA PCR investigative system is sensitive and specific,which can identify M.fortuitum at gene level.

Evaluation of quality control system for direct smear microscopy in National Tuberculosis Program in China

WANG Su-min,LIU Yu-hong,JIANG Guang-lu,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  209-210. 

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Quality Control(QC)of direct smear microscopy for acid-fast bacilli plays a great role in National Tuberculosis Program.Since 1994,the quality control system was established by National TB Control Center,and the work was further developed within five years.Until 1999,QC system covered 1 337 counties of 31 provinces,that is more widely than 98 counties of 20 provinces in 1994.The accordance rate of all the quality indexes continually high.The author analyzed the problems existed in QC and raised the resolve methods.

Extrapulmonary tuberculosis diagnosed by microcell plate hybridization assay

DU Qiong,YANG Zheng-lin,LUO Tao,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  211-213. 

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Objective Mycobacterium tuberculosis was detected by the method combining polymerase chain reaction(PCR),hybridization,ELISA,so that the founding of the pathogen can be thought as the diagnostic evidence of tuberculosis.Methods The Mycobacterium tuberculosis DNA was amplified by the specific primers labeled with biotin at 5’end,PCR products with biotin were hybridized with target DNA precoated in the microcell,then the hybrid can be detected by strepavidin labeled with HRP,the next process was similar to ELISA.ResultsAmong the 408 samples which may be contain Mycobacterium tuberculosis,the positive rate were 43.6 percent by PCR hybridization method,25.9 percent by culture,6.4 percent by direct microscopy(Ziehl-Neelsen staining)Conclusion PCR hybridization assay was sensitive specific and fast method for the dignosis of extrapulmonary.

Therapeutic effect and evaluation of Pasiniazid on multi-drug resistant tuberculosis

YU De-mei,MAO Xiao-hui,ZHANG Qian,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  214-216. 

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Objective To observe and evaluate the therapeutic effect in the treatment of multi-drug resistant tuberculosis(MDR-TB)with Pasiniazid.Methods By random group-matching,62 cases with MDR-TB were divided into MDR-TB trial group(group M with 31 cases)and control group(group C with 31 cases).Chemotherapy regimen:In group M,Pasiniazid was the main drug,more 3 other sensitive drug or new drugs which were not used before were selected based on its susceptibility.In group C,Pasiniazid was not used,while other drugs were the same to the group M.Results 9 months later,the sputum negative conversion rate in smear was 61% and the rate in cuture was 65% in group M,29% and 32% respectively in group C.The conversion rate in group M is much higher than that in group C(P<0.05 ).The check in 2 years showed that the positive conversion rate was 5% in group M,and 20% in group C.Conclusion The therapeutic regimen with Pasiniazid is favourable to sputum negative conversion and vanishing of the foci,with lower relapse rate.Due to its satisfactory therapeutic effect,it is worth of clinic practice.

The effect of pulmonary tuberculosis in different states of seriousness on the respiratory impedance

SUN Wei-hong,YAN Mei-zhen,WU Zhong.

Chinese Journal of Antituberculosis. 2000, 22(4):  217-219. 

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Objective To discuss the effect of pulmonary tuberculosis (PTB) in different states of illness on the respiratory impedance and evaluate the clinical significance of impulse oscillation(IOS) to determine the impedance in the patients with PTB.Methods The IOS indices of 60 patients with minimal PTB,48 cases of moderate advanced PTB,40 cases of far advanced PTB and 30 normal cases were compared with each other.Linear correlation was used to analyze the relationship between the impedance and ventilation indices of 148 cases.ResultsResonance frequenc frequency (Fres)、the total impedance(Zrs)、the total airway resistance(R₅)、the central airway resistance(R₂₀)、the peripheral airway resistance(R₅-R₂₀)and the peripheral capucitance(X₅) in the groups of PTB rose gradually with increasing of the seriousness of PTB.Compared with normal cases,the IOS indices of the patients with minimal PTB do not rose obviously(P>0.05).The IOS indices except R₂₀ rose obviously(P0.05)in the patients with moderate advanced PTB.The IOS indices of the patients with far advanced PTB rose obviously(P0.01).The negative correlation was found between IOS indices with the exception of X₅ and ventilation indices.The positive correlation was found between X₅ and ventilation indices.The correlation relationship between Fres and MVV are strongest in all.Conclusion The differences of effect in the patients with PTB on the impedance are very great.The applied foreground of IOS in the clinical PTB will be good.

A study on preventive effect of Mycobacterium vaccae vaccine for M.tuberculosis infected people

LIU Yuan-dong,JIN Xiao-hong,LI Zi-jian,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  220-221. 

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Objective To observe preventive effect of Mycobacterium vaccae vaccine for M.tuberculosis infected people.Methods and Result People aged from 18 to 45 whose PPD test Results are strong positive are divided into three groups at random.The average induration diameter of Mycobacterium vaccae vaccine group decreases significantly after having been injected three months,The number of those who have blister or necrosis also decrease greatly.While taking INH group and nontreatment group have no difference.Five people fell ill one year later,one from taking INH group,the other four from comparative group.No patients are found in Mycobacterium vaccae vaccine group.Conclusion Mycobacterium vaccae vaccine has better preventive effect for M.tuberculosis infected people.

The observation of curative effect of IL-2 supplemented with short-course chemotherapy for 50 cases of smear-positive pulmonary tuberculosls accompanying hepatitis B

ZHU Jie,SHI Nan-feng,CEN Long-gen.

Chinese Journal of Antituberculosis. 2000, 22(4):  222-224. 

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Objective To improve the curative effect and reduce side effect in the treatment of smear-positive pulmonary tuberculosis accompanying hepatitis B.Methods Use Interleukin-2(IL-2) in a daily dose of 20000 U supplemented with 2SHRZ/4H₃R₃ for 50 patients and contrast with 23 patients treated by 2SHRZ/4H₃R₃ and ordinary liver-curing medicine.Results The sputum negative conversion rates,HBeAg and HBV-DNA from positive to negative of the active group after 6 months themotherapy were 96.0%,70.4% and 71.4% respectively,which is obviously higher than 65.3%,8.3%and 14.3% of the control group (P<0.01).In the meantime,both the hepatic damage rate and drug withdrawal rate of the former were 0,Which is also obviously lower than the latter 26.1%(P<0.01),the recurrence rate of sputum,the conversion rates of HBeAg and HBV-DNA from positive to negative of the active group were 0,10.5% and 10.0% and the rates of control group were 6.7%,0,50.5% respectively according to a two-year follow-up examination,which indicatng less difference between active and control groups.Conclusion IL-2 is effective in antituberculosis,inhibit of reproduction of hepatitis B virus,as well as in reliving liver pathological process and reducing hepatic damage by antituberculous drugs.

Clinical observation on the role of spirulina in antituberculous agent induced hepatic damage

HE Lian-fu,LIU Liang-ping,WU Shi-lin.

Chinese Journal of Antituberculosis. 2000, 22(4):  225-226. 

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Objective To observe and decrease the anti-tuberculosis drug’s side effect on the liver.Methods Using spirin and antituberculous drug.three spirin capsules three times a day.Results At the end of 6 months,spirin therapy group’s side effect(on the liver)rate was 2.4% and the control group was 15.5%,the difference was obvious(P<0.01 ).Spirin has no side effect.Conclusion Anti-tuberculous drug’s side effect on the liver can be reduced allied with spirin.It is worthy of further exploration.

The application of ultrasound in the diagnosis of renal tuberculosis

SONG Xue-liang,WANG Ying-nian,MEI Hong,et al.

Chinese Journal of Antituberculosis. 2000, 22(4):  227-228. 

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Objective To study the application of ultrasond in the diagnosis of renal tuberculosis.Methods38 cases of renal tuberculosis were collected in our hospital and diagnosed by Aloka SSD-256 and THSHIBA SAL-38B ultrasound diagnostic apparatus.Among these case,23 were proved by surgery and pathology,9 were proved by X ray intravenous urography,6 were proved by the finding of acid fast bacillus in urine.Results The diagnostic accordance rate of the ultrasound is 86.8%,and that of X ray intravenous urography is 23.7%,and that of the positive result of acid fast bacillus in urine is 15.8%.Conclusion For the diagnosis of renal tuberculosis,ultrasound has the advantages of high accordance rate,simplicity,and no trauma.If combined with clinical materials and other examination methods,the diagnostic accordance rate can be improved.