Abstract: Objective To observe and evaluate the therapeutic effect in the treatment of multi-drug resistant tuberculosis(MDR-TB)with Pasiniazid.Methods By random group-matching,62 cases with MDR-TB were divided into MDR-TB trial group(group M with 31 cases)and control group(group C with 31 cases).Chemotherapy regimen:In group M,Pasiniazid was the main drug,more 3 other sensitive drug or new drugs which were not used before were selected based on its susceptibility.In group C,Pasiniazid was not used,while other drugs were the same to the group M.Results 9 months later,the sputum negative conversion rate in smear was 61% and the rate in cuture was 65% in group M,29% and 32% respectively in group C.The conversion rate in group M is much higher than that in group C(P<0.05 ).The check in 2 years showed that the positive conversion rate was 5% in group M,and 20% in group C.Conclusion The therapeutic regimen with Pasiniazid is favourable to sputum negative conversion and vanishing of the foci,with lower relapse rate.Due to its satisfactory therapeutic effect,it is worth of clinic practice.

Key words: MDR-TB, Pasinizid, Drug therapy