The research progress on the relationship between serum albumin and its derivative biomarkers and chronic obstructive pulmonary disease

doi:10.19982/j.issn.1000-6621.20240424

Abstract

Abstract:

Chronic obstructive pulmonary disease (COPD) is a widespread chronic inflammatory lung disease characterized by airflow limitation and partial irreversibility. The pathogenesis of COPD is complex, involving inflammatory responses, oxidative stress, and proteases anti-proteases imbalance. Serum albumin (ALB) and its derivative biomarkers, as bioindicators of nutritional status and inflammatory response, play an important role in the pathogenesis, disease assessment, and prognosis of COPD. At present, no comprehensive review on the relationship between COPD and serum albumin and its derivative biomarkers has been published. This review synthesizes the latest research findings to deepen our understanding of the role of these biomarkers in COPD and to highlight their potential research value.

Key words: Pulmonary disease, chronic obstructive, Serum albumin, Biological markers, Review literature as topic

CLC Number:

R563

Fu Ying, Xiong Yangyang, Fang Si, Li Chuanxiang, Guo Hongrong. The research progress on the relationship between serum albumin and its derivative biomarkers and chronic obstructive pulmonary disease[J]. Chinese Journal of Antituberculosis, 2025, 47(2): 231-236. doi: 10.19982/j.issn.1000-6621.20240424

Figures/Tables 1

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生物标志物	作用
ALB	影响呼吸肌功能,与住院时间和死亡率相关
AGR	反映感染状态,与住院时间相关
CAR	预测再入院、频繁加重风险和死亡率,评估营养风险
BAR	预测住院病亡率和30d、90d死亡风险
NPAR	与住院病亡率和5年内全因死亡率相关
FAR	反映炎症水平,提示急性加重风险
RAR	与ICU死亡率和预后不良相关
HALP	预测ICU死亡风险和再入院风险
PNI	预测呼吸衰竭和死亡率