西他沙星抗结核分枝杆菌的研究进展

doi:10.19982/j.issn.1000-6621.20250295

摘要/Abstract

摘要：

全球结核病疫情严峻,中国仍是结核病高负担国家之一。传统氟喹诺酮类药物因交叉耐药及不良反应限制疗效,西他沙星凭双靶点机制及良好的组织渗透性(肺泡衬液浓度/血浆浓度比为54%),对耐多药结核病、利福平耐药结核病、准广泛耐药结核病、广泛耐药结核病均具有良好的抗菌活性,其早期杀菌活性优于左氧氟沙星和莫西沙星,且不良反应可控,且首例经文献记录的准广泛耐药结核病患者已成功采用含西他沙星的方案治愈。笔者阐述了西他沙星治疗结核病的研究进展,以期为西他沙星临床应用提供循证参考。

关键词: 西他沙星, 结核, 抗结核药, 综述文献(主题)

Abstract:

The global tuberculosis epidemic remains severe, and China continues to be classified among the tuberculosis high-burden countries. Conventional fluoroquinolones are increasingly limited by cross-resistance and adverse-event profiles. Sitafloxacin, distinguished by its dual-target mechanism and good tissue penetration (The ratio of alveolar lining fluid concentration to plasma concentration is 54%), exhibits potent bactericidal activity against multidrug-resistant, rifampicin-resistant, pre-extensively drug-resistant, and extensively drug-resistant Mycobacterium tuberculosis strains. Comparative studies indicate that its early bactericidal activity surpasses that of levofloxacin and moxifloxacin, while its safety profile remains acceptable. Notably, the first documented case of pre-extensively drug-resistant tuberculosis has been successfully treated with sitafloxacin-based regimens. This review synthesizes recent advances in the use of sitafloxacin for tuberculosis therapy, aiming to provide an evidence-based reference for its clinical application.

Key words: Sitafloxacin, Tuberculosis, Antitubercular agents, Review literature as topic

中图分类号:

王雪钰, 初乃惠, 聂文娟. 西他沙星抗结核分枝杆菌的研究进展[J]. 中国防痨杂志, 2026, 48(2): 299-303. doi: 10.19982/j.issn.1000-6621.20250295

Wang Xueyu, Chu Naihui, Nie Wenjuan. Research progress on the anti-Mycobacterium tuberculosis activity of sitafloxacin[J]. Chinese Journal of Antituberculosis, 2026, 48(2): 299-303. doi: 10.19982/j.issn.1000-6621.20250295

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