结核病实验室诊断技术研发新进展

doi:10.19982/j.issn.1000-6621.20220535

中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (5): 446-453.doi: 10.19982/j.issn.1000-6621.20220535

结核病实验室诊断技术研发新进展

李姗姗¹, 王玉峰², 舒薇³, 逄宇¹()

¹ 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所细菌免疫学实验室, 北京 101149
² 北京结核病诊疗技术创新联盟, 北京 101149
³ 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所/中国疾病预防控制中心结核病防治临床中心, 北京 101149

收稿日期:2023-01-19 出版日期:2023-05-10 发布日期:2023-04-25
通信作者: 逄宇 E-mail:pangyupound@163.com
基金资助:
中华预防医学会加强重大传染病防控的政策倡导项目(INV-035022)

Progress and reflections on development of laboratory diagnostic technology for tuberculosis

Li Shanshan¹, Wang Yufeng², Shu Wei³, Pang Yu¹()

¹ Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
² Innovation Alliance on Tuberculosis Diagnosis and Treatment, Beijing 101149,China
³ Clinical Center on TB Control, Chinese Center for Disease Control and Prevention/Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149,China

Received:2023-01-19 Online:2023-05-10 Published:2023-04-25
Contact: Pang Yu E-mail:pangyupound@163.com
Supported by:
Chinese Preventive Medicine Association’s Policy Advocacy for Improving Prevention and Control of Major Infectious Diseases(INV-035022)

摘要/Abstract

摘要：

结核病的精准防控需要快速、准确的实验室诊断技术。自1882年罗伯特·科赫发现结核分枝杆菌以来,结核病诊断技术经历了从传统的病原学诊断到免疫学和分子生物学诊断的巨大飞跃,然而这种诊断技术的发展仍然与实现2035年终止结核病的宏伟目标存在一定差距。作者在梳理既往结核病诊断技术研发进展的基础上,围绕结核病防控的核心诊断需求,探究未来实验室诊断的重要发展管线。

关键词: 分枝杆菌,结核, 分子诊断技术, 感染, 诊断

Abstract:

Rapid and accurate laboratory diagnostic techniques are of great importance for the prevention and control of tuberculosis (TB). Since the discovery of Mycobacterium tuberculosis by Robert Koch in 1882, significant achievements have been made in the development of TB diagnosis from traditional etiological diagnostics to immunological and molecular diagnostics. Nevertheless, the current diagnostic technologies remain unable to meet current requirements, thereby hampering the achievement of the End TB Strategy by 2035. In view of these challenges, the authors discuss the core diagnostic needs of TB prevention and control, and explore the important development pipeline of future laboratory diagnosis.

Key words: Mycobacterium tuberculosis, Molecular diagnosis technology, Infection, Diagnosis

中图分类号:

李姗姗, 王玉峰, 舒薇, 逄宇. 结核病实验室诊断技术研发新进展[J]. 中国防痨杂志, 2023, 45(5): 446-453. doi: 10.19982/j.issn.1000-6621.20220535

Li Shanshan, Wang Yufeng, Shu Wei, Pang Yu. Progress and reflections on development of laboratory diagnostic technology for tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(5): 446-453. doi: 10.19982/j.issn.1000-6621.20220535

图/表 1

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结核病实验室诊断技术研发新进展

Progress and reflections on development of laboratory diagnostic technology for tuberculosis

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