关键词: 抗结核药, 药物利用, 北京市

Abstract: Objective To understand clinical use of anti-tuberculosis drugs in Beijing Haidian Hospital and provide evidence for rationale use of anti-tuberculosis drugs in general hospitals. Methods Medication rationality was evaluated by DDDs, DDC and DUI calculated based on total use, money and days using drugs of first-line anti-tuberculosis drugs in 2010 using computer information system. Sixty-two patients were detected from 17321 in-hospital patients, and their reasons for medication, regimen, and dosage were analyzed. Results The first-line drugs which can be used in Beijing Haidian Hospital were rifampicin(RFP), isoniazid(INH), ethambutol(EMB),pyrazinamide(PZA), and streptomycin(SM) The whole year’s expense on all first-line anti-tuberculosis drugs was 1988.05 RMB. The DUI value of RFP, EMB and PZA were 0.85, 0.86 and 0.96, respectively. Forty-eight patients were treated with anti-tuberculosis drugs as treatment aim among 62 patients who received the first-line anti-tuberculosis drugs. Among 32 confirmed and clinical diagnosed patients, only 43.8%（14/32）received HRZE regimen. Addition of levofloxacin(Lfx) to the regimen in patients who received second-line anti-tuberculosis drug accounted for 79.2%（38/48）.Conclusion The dosage of antituberculosis drugs was less in Haidian hospital. The rate of standardized clinical use of antituberculosis drugs is low and some agent dosage isn’t enough.  Standard  treatment of tuberculosis should be strengthened in the future.

Key words: Antitubercular agents, Drug utilization, Beijing city