关键词: 结核/治疗, 药物疗法, 免疫疗法, 内窥镜检查, 临床方案

Abstract: Some progress had been made in the clinical treatment of tuberculosis in 2013. Headed to Bedaquiline, the new drugs had been used further in clinical. Vaccine research had new attempts in nanotechnology, adjuvant, etc. Preliminary results of an oral formulation V7 in immunotherapy showed that it has a certain application prospect. The report affirmed interventional treatment effect of bronchoscopy balloon dilation for tuberculous bronchial stenosis. Thoracoscopy treatment of tuberculosis encapsulated pleural had shown satisfactory effect. MDR-TB patients got better results through selecting the appropriate indications for surgery. Drug resistant tuberculosis of bone and joint needs a personalized surgical plan on the basis of individualized treatment. Standardized regimen for MDR-TB had some effect, which moxifloxacin-contained regimens may be better than levofloxacin, and the efficacy of Group 5 drug-contained chemotherapy regimens needs to be more observation. The WHO recommended isoniazid preventive anti-TB treatment for HIV patients. HIV patients with tuberculosis were recommended at least 6-month of isoniazid therapy continued the basis of standard programs to prevent recurrence. For making anti-TB treatment programs for large proportion of elderly TB patients, the drug side effects, the patient’s underlying disease and concomitant medications, taking aminoglycoside anti-TB drugs with caution, appropriate choosing of second-line drugs, and dose adjustment should be fully considered. Information of childhood tuberculosis was serious shortage, not only the lack of effective methods for diagnosis, but also attention should be strengthened because of the rapid progress of tuberculosis infection in childhood. In addition to streptomycin, the remaining first-line anti-TB drugs were safe for pregnant TB patients and short course chemotherapy was also effective and teratogenic effects and liver toxicity had not been confirmed. Drug-induced liver injury was the most common adverse reactions of anti-TB drugs. Expert advice for diagnosis and handling of drug-induced liver injury caused by anti-tuberculosis drug made by Chinese Society for Tuberculosis, Chinese Medical Association was annual important progress in 2013,while opinion of preventive protection treatment of liver was not uniform.

Key words: Tuberculosis/therapy, Drug therapy, Immunotherapy, Endoscopy, Clinical protocols