关键词: 结核, 肺/药物疗法, 复发, 临床方案, 治疗结果

Abstract: Objective  To explore the status and effect of standard treatment regimens of retreatment pulmonary tuberculosis patients in Beijing. Methods  This was a retrospective study. The bacteriologically confirmed retreated pulmonary tuberculosis cases registered from 2009 to 2010 in Beijing were enrolled and divided into rifampin-sensitive (138 cases) and rifampin-resistant (39 cases)groups, according to the results of drug susceptibility test. The cases in each group were divided into isoniazid-sensitive and isoniazid-resistant groups. There were 114 cases sensitive to both isoniazid and rifampin, 24 resistant to isoniazid and sensitive to rifampin, 12 sensitive to isoniazid and resistant to rifampin, and 27 resistant to both isoniazid and rifampin. Standard treatment regimens（2HRZES/6HRE）were applied, and the effect was retrospectively analyzed. Results  In isoniazid-sensitive and resistant groups, the sputum conversion rates were 92.9%（117/126）and 66.7%（34/51）,and the treatment success rates were 87.3%（110/126）and 60.8%（31/51）respectively. There was no statistical significant difference in the sputum conversion and the treatment success between two groups(χ²_MH value were 2.183 and 1.974, both P_MH value >0.05).In rifampin-sensitive and resistant groups, the sputum conversion rates were 94.2%（130/138） and 53.8%（21/39）,and the treatment success rates were 88.4%（122/138） and 48.7%（19/39） respectively. The differences in the sputum conversion and the treatment success between two groups were statistical significant (χ²_MH values were 16.199 and 12.686, both P_MH value ＜0.001). Conclusion  The effect of standard regimens of rifampin-sensitive pulmonary tuberculosis has been approved, while the rationality of applying standard regimens to those rifampin-resistant cases needs to be discussed.

Key words: Tuberculosis,Pulmonary/drug therapy, Recurrence, Clinical protocols, Treatment outcome