[1]World Health Organisation. Global tuberculosis control: WHO report 2011[R/OL]. World Health Organization,2011[2012-04-20]. http://www.who.int/tb/publications/global_report/2011/gtbr11_full.pdf.[2]吴雪琼. 新型结核病疫苗的研究现状与发展趋势.中国防痨杂志,2012,34(3):133-137.[3]Ramalingam B, Baulard AR, Locht C, et al. Cloning, expression, and purification of the 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Protein Expr Purif,2004, 36(1): 53-60.[4]Harth G, Horwitz MA. Export of recombinant Mycobacterium tuberculosis superoxide dismutase is dependent upon both information in the protein and mycobacterial export machinery. A model for studying export of leaderless proteins by pathogenic mycobacteria. J Biol Chem,1999,274(7): 4281-4292.[5]Miki K, Nagata T, Tanaka T, et al. Induction of protective cellular immunity against Mycobacterium tuberculosis by recombinant attenuated self-destructing listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPB/MPT51. Infect Immun,2004,72(4): 2014-2021.[6]Bethunaickan R, Baulard AR, Locht C, et al. Antibody response in pulmonary tuberculosis against recombinant27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Scand J Infect Dis, 2007,39(10):867-874.[7]Siev M, Yu X, Prados-Rosales R,et al. Correlation between serum and plasma antibody titers to Mycobacterial antigens. Clin Vaccine Immunol,2011, 18(1): 173-175.[8]Silva BD, da Silva EB, do Nascimento IP, et al. MPT-51/CpG DNA vaccine protects mice against Mycobacterium tuberculosis. Vaccine,2009, 27(33): 4402-4407.[9]Wang LX, Nagata T, Tsujimura K, et al. Identification of HLA-DR4-restricted T-cell epitope on MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis using MPT51 overlapping peptides screening and DNA vaccination. Vaccine, 2010,28(8):2026-2031.[10]Braunstein M, Espinosa BJ, Chan J, et al.SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Mol Microbiol,2003,48(2):453-464.[11]Edwards KM, Cynamon MH, Voladri RK, et al. Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis. Am J Respir Crit Care Med,2001,164(12):2213-2219.[12]Khera A, Singh R, Shakila H, et al. Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis.Vaccine,2005,23(48/49):5655-5665.[13]Jain R, Dey B, Khera A, et al. Over-expression of superoxide dismutase obliterates the protective effect of BCG against tuberculosis by modulating innate and adaptive immune responses.Vaccine,2011, 29(45):8118-8125. |