关键词: 结核, 抗药性,多药, 系统综述方法

Abstract: Objective To analyze drug resistance of Mycobacterium tuberculosis in different age group in recent years,and to provide scientific evidence for further development of TB control poli-cy.Methods Systematic Review was applied to comprehensively analyze the status of drug resist- ance of Mycobacteriurn tuberculosis in different age group from 1996 to 2007.Results According to the systematic analysis of the literature in the past 10 years,the primary drug resistance rates were 28.0%,31.8% and 28.9% respectively in young group,middle age group and old group.There was significant difference between young group and middle age group(P<0.05),and there were no significant differences between young group and old group,middle age group and old group (P>0.05);the rates of acquired drug resistance were 70.1%,66.1% and 57.0% respectively in young group,middle age group and old group.There were significant differences among them(P<0.05). The frequency of primary drug resistance from high to low in order were S,R,H and E in young group and middle age group,and H,S,R and E in old group;the acquired drug resistance frequen- cy were H,R,S and E in all groups,the acquired resistance rate to H in young group was 71.0%, which was the highest among three groups.The rate of primary multi-drug resistance in middle age group was 4.2 %,higher than that in young group and old group,there were significant differences between young group and middle age group,middle age group and old group(P<0.05);the rate of acquired multi-drug resistance in young group was 45.2%,much higher than that in middle age group(35.2%)and old group(19.7%),there were significant differences among them(P<0.05).The rate that the drug resistance happens along with duration of medication is different a-mong different age group(P<0.05);the drug resistance rates in the group with 1～3 month of medication,the group with 4～6 month of medication and the group with more than 6 month of medication were 44.5%,66.8% and 83.1% respectively.There were significant differences among them(P<0.05),and the drug resistance happens fastest in the young group.Conclusions Prima- ry drug resistance or acquired drug resistance varies in different age groups with special characteris-tics,which is of important meaning to clarify the reason of drug resistance.It is suggested that great attention should be paid to tuberculosis cases in age group of high drug resistance.

Key words: Tuberculosis, Drug resistance,multiple, Systematic review