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中国防痨杂志 ›› 2001, Vol. 23 ›› Issue (1): 30-32.

• 论著 • 上一篇    下一篇

抗结核组合药对HBVM阳性肺结核病人肝功能影响的观察

陈斯沧1；陈红旗2；   

  1. 1.浙江省磐安县人民医院 322300； 2.浙江省磐安县结核病防治所；
  • 出版日期:2001-01-10 发布日期:2001-11-03

Obervation of the effect on liver function in pulmonay tuberculosis with positive HBVM treated by antituberculotic combination

CHEN Si cang,CHEN Hong qi.   

  1. The peoples Hospitol of Pan’an county,Zhejian 322300
  • Online:2001-01-10 Published:2001-11-03

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摘要： 目的　观察抗结核组合药对HBVM阳性肺结核病人肝功能的影响。方法 比较HBVM阳性和阴性肺结核病人组合药治疗前后肝功能损害情况。结果 HBVM阳性病人肝损率比阴性者明显增高(P<0.01);其中“模式Ⅰ”与“模式Ⅱ”病人肝损率差异不显著(P>0.05),而“模式Ⅰ+Ⅱ”病人肝损率比“模式Ⅲ”高(P<0.05)。结论 组合药致肝功能损害,HBVM阳性病人比阴性多见,尤以“模式Ⅰ、Ⅱ”病人更易发生,可能与用药前肝脏病理损害严重程度有关。应慎用组合药并积极采取综合措施防范。

关键词: 结核,肺, 乙型肝炎病毒标志物, 药物疗法

Abstract: Objective To observe the effect on liver function in pulmonary tuberculosis with positive HBVM treated by antituberculotic combination.Methods Compare the damage to the liver function of the HBVM positive or negative tuberculosis patient before and after taking the antituberculotic combination.Results The damage to the liver function of the HBVM positive tuberculosis patient is much higher than negative tuberculosis patient(P<0.01 ),and the damage to the “Model-Ⅰ”and “Model Ⅱ”patient varies little(P>0.05 ).But the damage to the liver function of “Model-Ⅰ+Ⅱ”patients is higher than that of “Model Ⅲ”(P<0.05 ).Conclusion The antituberculotic combination will damage the liver function of HBVM positive tuberculosis patients and negative tuberculosis patients,“Model-Ⅰ”and “Model Ⅱ”patients are easily affected.The combination drug must be taken carefully and comprehesive prevention measures must be taken ahead.

Key words: Tuberculosis,pulmonary, Hepatitis B Virus Marker, Drug therapy

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