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中国防痨杂志 ›› 2011, Vol. 33 ›› Issue (2): 109-112.

• 论著 • 上一篇    下一篇

耐多药肺结核相关因素探讨

王海东1 谢艳光2 闫兴录2 李发滨2 范冀缓3 胡冬梅1 何广学1   

  1. 中国疾病预防控制中心 北京 102206; 黑龙江结核病防治研究所 哈尔滨 150030; 河南省疾病预防控制中心 郑州 450016
  • 收稿日期:2010-07-09 出版日期:2011-02-20 发布日期:2012-01-19
  • 通信作者: 何广学,谢艳光 E-mail:heguangxue@chinatb.org, htccxyg@163.com
  • 基金资助:

    结核病感染控制新技术平台的研究(2009ZX10004-741)

Risk factors on the development of multi-drug resistance tuberculosis

Wang Haidong,Xie Yanguang,Yan Xinglu,Li Fabin,Fan Jihuan,Hu Dongmei,He Guangxue   

  1. 1.Chinese Center for Disease Control and Prevention; Beijing 102206; China; 2.Heilongjiang Tuberculosis Research Institute; Harbin 150030; 3.Henan Center for Disease Control and Prevention; Zhengzhou 450016; China
  • Received:2010-07-09 Online:2011-02-20 Published:2012-01-19
  • Contact: He Guangxue,Xie Yanguang E-mail:heguangxue@chinatb.org, htccxyg@163.com

摘要: 目的 探讨黑龙江省结核病耐药监测项目的 纳入患者中耐多药结核病(MDR-TB)患者的相关因素。方法 通过对结核病耐药监测项目中MDR-TB患者进行问卷调查,并对其纳入结核病耐药监测项目时登记的信息进行收集与整理。采用SPSS13.0对数据进行分析。结果 复治患者中的MDR-TB患者比例较高,影响初复治患者产生耐多药的主要因素为居住地、曾接受治疗的天数和曾接受治疗的次数。结论 接受不规律治疗的时间越长,次数越多产生耐多药的可能性越大。应实施高质量的DOTS策略从根本上减少MDR-TB患者的产生。

关键词: 结核, 肺, 结核, 抗多种药物性, 抗药性, 多种, 细菌

Abstract: Objective To analyze the factors affecting multi-drug resistance tuberculosis (MDR-TB) development among recruit patients of drug resistant (DR) surveillance programme in Heilongjiang.  Methods Questionnaire survey was conducted on all MDR-TB cases of DR surveillance programme, and their information recorded was collected and analyzed.  Results The proportion of MDR-TB patients among retreatment cases was higher, the main factors affecting MDR-TB development were residence place, number of days of prior treatment and times of prior treatment. Conclusion The longer prior irregular treatment and the more prior irregular treatment received, the more likely MDR-TB occur. Implementation of high quality DOTS can reduce MDR-TB ultimately.

Key words: tuberculosis, pulmonary, multidrug-resistant, drug-resistance, multiple, bacterial