关键词: 结核, 肺/药物疗法, 抗药性, 细菌, 药物监测, 福建省

Abstract: Objective To understand the drug resistant status of tuberculosis in Fujian province,evaluate the effect of TB control，and provide evidence base for TB control policy development.  Methods 30 counties were selected for TB survey sites by stratified cluster sampling method，all the newly registered smear positive cases during investigation received sputum culture examination,we plan to enroll a total of 1230 new cases of smear positive, 41 new cases in each site and all retreatment patients. The drug susceptibility testing of H，R，S，E，Ofx and Km were performed by proportion method. Results We enrolled a total of 1579 patients(1223 new cases and 356 retreatment cases)，of which，2.3%(36/1579)was contaminated, the culture negative rate of smear positive patients was 3.9%(61/1579)；1452 cases were performed DST，and 1389 cases were identified as MTBC,new and retreatment cases accounting for 79.8%(1109/1389)and 20.2%(280/1389)，respectively. The total drug resistant rate was 24.0%(333/1389),the rate of multi-drug resistance(MDR)was 5.7%(79/1389), the extensively drug resistant(XDR)rate was 0.1%(1/1389). The primary drug resistant rate was 20.7%(230/1109)，the primary MDR rate was 3.2%(35/1109)，the acquired drug resistant rate was 36.8%(103/280)，the acquired MDR rate was 15.7%(44/280)，the acquired XDR rate was 0.4%(1/280). We found 41 patterns of drug resistant MTBC spectrum，including 6 patterns of mono-drug resistance，24 patterns of resistance to 2 or more drugs but not MDR，and 11 MDR(comprising 1 patter of XDR)patterns.  Conclusion The drug resistant tuberculosis in Fujian province is in a low level,but the resistance spectrum is diverse and complex,therefore,we need to further strengthen the drug resistant TB control work.

Key words: Tuberculosis, pulmonary/drug therapy, Drug resistance, bacterial, Drug monitoring, Fujian province