[1] Rowland R, McShane H. Tuberculosis vaccines in clinical trials. Expert Rev Vaccines,2011,10(5):645-658.[2] 尹文东,于庭,梁艳,等.结核分枝杆菌重组Ag85A、Ag85B蛋白免疫原性的研究.中国实验诊断学,2011,15(10):1618-1621.[3] Lu D, Garcia-Contreras L, Muttil P,et al. Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity.AAPS J, 2010,12(3):338-347.[4] Giri PK, Verma I, Khuller GK. Adjunct immunotherapy with Ag85 complex proteins based subunit vaccine in a murine model of Mycobacterium tuberculosis infection. Immunotherapy, 2009,1(1):31-37.[5] 黎友伦,罗永艾,王国治.细胞因子及其受体在结核免疫中的作用.国外医学内科学分册,2005,32(4):146-149.[6] 师长宏,范雄林,柏银兰,等.结核分枝杆菌Ag85B-ESAT6 融合蛋白在小鼠体内诱导的免疫应答及其保护力.第四军医大学学报,2004,25 (18):1633-1636. [7] Langermans JA, Doherty TM, Vervenne RA,et al.Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.Vaccine,2005,23(21):2740-2750.[8] McShane H, Pathan AA, Sander CR, et al.Recombinant mo-dified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.Nat Med,2004,10(11):1240-1244.[9] Scriba TJ, Tameris M, Mansoor N, et al.Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.Eur J Immunol,2010,40(1):279-290.[10] Aeras, University of Oxford,European, Developing Countries Clinical Trials Partnership (EDCTP). Protective efficacy against tuberculosis (TB) disease, safety, and immunogenicity of MVA85A/AERAS-485 in HIV-infected adults[EB/OL].[2012-11-25].http://clinicaltrials.gov/ct2/show/NCT01151189?term=MVA+85A&rank=2.htm. [11] van Dissel JT, Soonawala D, Joosten SA, et al.Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.Vaccine,2011,3(29):2100-2109. [12] Aeras, Crucell Holland BV. Safety and immunogenicity of AERAS-402 in HIV-infected, Bacillus Calmerre-Guerin(BCG)-vaccinated adults[EB/OL].[2012-11-15].http://clinicaltrials.gov/ct2/show/NCT01017536?term=AERAS-402&rank=2.htm. [13] Horwitz MA, Harth G. A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis.Infect Immun,2003,71(4):1672-1679.[14] Hoft DF, Blazevic A, Abate G, et al. A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis,2008,198(10):1491-1501.[15] Sugawara I, Sun L, Mizuno S, et al. Protective efficacy of recombinant BCG Tokyo (Ag85A) in rhesus monkeys (Macaca mulatta) infected intratracheally with H37Rv Mycobacterium tuberculosis. Tuberculosis (Edinb),2009,89(1):62-67. [16] Jain R, Dey B, Dhar N, et al.Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lung.PLoS One,2008,3(12):e3869.[17] Xu Y, Liu W, Shen H, et al.Recombinant Mycobacterium bovis BCG expressing the chimeric protein of antigen 85B and ESAT-6 enhances the Th1 cell-mediated response.Clin Vaccine Immunol,2009,16(8):1121-1126.[18] 王平,王丽梅,张薇,等.结核分枝杆菌Ag85B-ESAT-6融合蛋白重组耻垢分枝杆菌对小鼠的免疫原性研究.中国防痨杂志,2012,34(3):145-149.[19] 张灵霞,吴雪琼,董恩军.四种卡介苗重组疫苗对结核病的预防作用.实用医学杂志,2011,27(12):2115-2117.[20] Chang-hong S, Xiao-wu W, Hai Z, et al.Immune responses and protective efficacy of the gene vaccine expressing Ag85B and ESAT6 fusion protein from Mycobacterium tuberculosis.DNA Cell Biol,2008,27(4):199-207.[21] Fan X, Gao Q, Fu R.Differential immunogenicity and protective efficacy of DNA vaccines expressing proteins of Mycobacterium tuberculosis in a mouse model. Microbiol Res,2009,164(4):374-382.[22] 吴雪琼,李洪敏,史迎昌,等.结核分枝杆菌DNA疫苗抗结核作用的研究.中国生物制品学杂志,2002,1(6):340-345.[23] Liang Y, Wu X, Zhang J, et al.The treatment of mice infected with multi-drug-resistant Mycobacterium tuberculosis using DNA vaccines or in combination with rifampin.Vaccine, 2008,26(35):4536-4540.[24] Liang Y,Wu X,Zhang J,et al.Treatment of multi-drug-resis-tant tuberculosis in mice with DNA vaccines alone or incombination in mice chemotherapeutic drugs.Scand J Immunol,2011,74(1):42-46.[25] 梁艳,吴雪琼,张俊仙,等.结核分枝杆菌Ag85A/ESAT-6嵌合型质粒DNA疫苗和抗结核药物联合治疗小鼠耐药结核病的效果研究.中国防痨杂志,2007,29(5):382-385.[26] 胡静,吴雪琼,王丽华,等.结核分支杆菌Ag85B DNA疫苗构建、免疫原性及其保护效力.科学技术与工程,2006,6(13):1765-1770.[27] Tanghe A, D’Souza S, Rosseels V, et al. Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting. Infect Immun,2001,69(5):3041-3047. |