关键词: 结核, 胸膜/并发症, 肿瘤, 胸腔积液, C反应蛋白质, 腺苷脱氨酶, 诊断, 鉴别

Abstract: ObjectiveTo study the value of high-sensitive C-reactive protein (hs-CRP) and adnosine deaminase(ADA) in the diagnosis of tuberculous pleuritis. MethodsWe studied 116 consecutive cases with pleural fluid admitted in 2007. The patients with pleural fluid were divided into two groups: tuberculosis（TB），non-TB. The hs-CRP and ADA were detected, respectively, and included in receiver operating characteristic curve, which was used to determine cutoff values with the highest sensitivity and specificity. Results The level of hs-CRP and ADA in the TB group were (56.76±16.62) mg/L and (47.89±12.97) IU/L, respectively.they in non-TB group were (22.72±5.04) mg/L and (21.61±5.97) IU/L, respectively. The sensitivity and specificity of hs-CRP and ADA in the TB group were 98.6%, 97.6% and 95.9%, 95.2%, respectively. The area under the curve both hs-CRP and ADA was 0.999(0.998-1.001,95%CI), 0.993(0.982-1.003,95%CI), respectively. The sensitivity and specificity of the detection combined hs-CRP with ADA were 90.5% and 98.7%, respectively. ConclusionThe detection of hs-CRP and ADA in pleural fluid have important value for the diagnosis of tuberculous pleuritis.

Key words: tuberculosis,pleural/complications, neoplasms, pleural effusion, C-reactive protein, adenosine deaminase, diagnosis,differential