sFasL检测对结核性与恶性胸腔积液鉴别诊断价值的探讨

中国防痨杂志 ›› 2007, Vol. 29 ›› Issue (4): 324-327.

sFasL检测对结核性与恶性胸腔积液鉴别诊断价值的探讨

刘玉峰¹；刘加洪²；车文华¹；石玉桂¹；

1.青岛市胸科医院青岛 266043；2.青岛市中心医院青岛 266000；

出版日期:2007-04-10 发布日期:2007-11-03

Diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions

Liu Yufeng¹,Che Wenhua,Shi Yugui,et al.

1.Qingdao Chest Hospital of Shandong Province,Qingdao 266043,China

Online:2007-04-10 Published:2007-11-03

摘要/Abstract

摘要： 目的探讨sFasL对恶性胸腔积液与结核性胸腔积液鉴别诊断价值。方法应用ELISA法分别检测32例恶性胸腔积液和43例结核性胸腔积液中sFasL的含量,对结果进行统计学处理。结果结核性胸腔积液组sFasL(13.56±5.38 ng/ml)显著高于恶性胸腔积液组(5.72±2.59 ng/ml),二者具显著性差异(P＜0.001)。以10 ng/ml为临界值,胸腔积液中sFasL>10 ng/ml诊断为结核性胸腔积液的敏感性为81.4%(35/43),特异性为81.3%(26/32),临床诊断符合率为81.4%(61/75)。结论sFasL对结核性、恶性胸腔积液的鉴别诊断有临床实用价值。

关键词: sFasL, 恶性胸腔积液, 结核性胸腔积液, 酶联免疫吸附实验

Abstract: Objective To explore the diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions.Methods Using enzyme-linked immunosorbent assay(ELISA) method to detect the soluble FasL in 43 tuberculous pleural effusions and 32 malignant pleural effusions.Results The mean of soluble FasL of tuberculous pleural effussions(13.56±5.38ng/ml)was markedly higher than that of malignant pleural effusions(5.72±2.59ng/ml)(P＜0.001).If 10ng/ml of soluble FasL was regarded as cutoff value,the sensitivity,the specificity and accordance of diagnosing tuberculous pleural effusions were 81.4%,81.3% and 81.4%,respectively.Conclusion Soluble FasL might be a effective laboratory marks of differentiating tuberculous and malignant pleural effusions.

Key words: Soluble FasL, Malignant pleural effusions, Tuberculous pleural effusions, ELISA

刘玉峰,刘加洪,车文华,石玉桂,. sFasL检测对结核性与恶性胸腔积液鉴别诊断价值的探讨[J]. 中国防痨杂志, 2007, 29(4): 324-327.

Liu Yufeng¹,Che Wenhua,Shi Yugui,et al.. Diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions[J]. Chinese Journal of Antituberculosis, 2007, 29(4): 324-327.

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