HLA-DRB和ACE基因与肺结核的相关性分析

中国防痨杂志 ›› 2007, Vol. 29 ›› Issue (4): 327-329.

HLA-DRB和ACE基因与肺结核的相关性分析

时广利；胡秀玲；荣长利；张宝秋；宋长兴；

北京市结核病胸部肿瘤研究所北京 101149；

出版日期:2007-04-10 发布日期:2007-11-03

Association of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis

Shi Guangli,Hu Xiuling,Rong Changli,et al.

(Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)

Online:2007-04-10 Published:2007-11-03

摘要/Abstract

摘要： 目的探讨人类白细胞抗原(HLA)-DRB基因和血管紧张素转换酶(ACE)基因多态性与肺结核的相关性。方法采用聚合酶链反应-序列特异性引物法(PCR-SSP)对肺结核组和健康对照组进行HLA-DRB和ACE基因分型。结果肺结核组HLA-DRB₁^*15等位基因的频率显著高于对照组(P＜0.05)；复治和耐药肺结核组ACE基因的I/D基因型频率显著高于初治和无耐药组(P＜0.05)。结论HLA-DRB₁^*15等位基因及ACE基因的I/D基因型与肺结核密切相关。

关键词: HLA-DRB基因, ACE基因, 结核,肺

Abstract: Objective To analyze the relation of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis.Methods PCR/SSP was used to identify the HLA-DRB and ACE genotype in pulmonary tuberculosis group and control group.Results The frequency of HLA-DRB₁^*15 allele in pulmonary tuberculosis group was significantly higher than that in control group(P＜0.05).The frequency of ACE I/D genotype in retreatment and drug-resistant pulmonary tuberculosis group was significantly higher than that in initial and drug-sensitive group(P＜0.05).Conclusion The HLA-DRB₁^*15 allele and the I/D genotype of ACE gene were evidently associated with pulmonary tuberculosis.

Key words: Human leukocyte antigen gene, Angiotensin converting enzyme gene, Pulmonary tuberculosis

时广利,胡秀玲,荣长利,张宝秋,宋长兴,. HLA-DRB和ACE基因与肺结核的相关性分析[J]. 中国防痨杂志, 2007, 29(4): 327-329.

Shi Guangli,Hu Xiuling,Rong Changli,et al.. Association of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2007, 29(4): 327-329.