关键词: 抗药性,多药, 结核肺, 生命质量

Abstract: Objective To evaluate health and curative effect of patients with multi-drug resistant pulmonary tuberculosis(MDR-TB) from the angle of the quality of life(Qol). Methods To measure and evaluate Qol for 100 patients with MDR-TB and 100 natural persons using SF-36 instrument.To state and accomplish 92 patients Qol.The investigation time was before,3 months after treatment and 1 year after treatment.The changes of Qol scores were evaluated in total and many domains To evaluate curative effect using paired t test and analysis of variance.Single and multiple stepwise regression analysis were made to evaluate factors affecting Qol. Results Between the patients with MDR-TB and the control in the total Qol scores and eight domains,there were significant differences(P<0.01),total Qol scores and eight domains in 3 months or 1 year after treatment were higher than before therapy,there were significant differences(P<0.01).Between 1 year after therapy in the total Qol scores and PF、 PR、GH、 VT、 SF、 ER、 MH’s domains were lower than control groups,there were significant differences(P<0.05).The main factors affecting the Qol of patients with MDR-TB were cultural level,kinds of drug resistant and reduction of counts of white blood cell. Conclusion There were comprehensive reduces in the quality of life of patients with MDR-TB. The quality of life of patients with MDR-TB had increased significantly but hadn’t recovered completely 1 year after therapy.Early intensive therapy could increase the quality of life of patients with MDR-TB.The main factors affecting the Qol of patients with MDR-TB are cultural level,kinds of drug resistant and reduction of counts of white blood cell.

Key words: Drug resistant,multiple, Pulmonary tuberculosis, Quality of life