化学药物联合免疫调节剂治疗复治肺结核的疗效观察

中国防痨杂志 ›› 2002, Vol. 24 ›› Issue (3): 137-139.

化学药物联合免疫调节剂治疗复治肺结核的疗效观察

冀澍雨¹；刘瑾²；颜鸿飞¹；张继兴²；苏孟²；耿凤英³；

1.沈阳市胸科医院沈阳 110044；2.沈阳市结核病防治所沈阳 110044；3.沈阳市皇姑区结核病防治所沈阳 110044；

出版日期:2002-03-10 发布日期:2002-11-03

The therapeutic effect of chemotherapy combined with immunotheraphy on retreated pulmonary tuberculosis

JI Shu-yu¹,LIU Jin,YAN Hong-fei,et al.

1.Shenyang Chest Hospital,Shenyang 110044

Online:2002-03-10 Published:2002-11-03

摘要/Abstract

摘要： 目的　观察化学药物联合免疫调节剂治疗难治、复治肺结核的临床效果。方法 226例涂阳病人随机分为治疗组及对照组，两组化疗方案相同，治疗组加用卡介菌多糖核酸，观察疗效。结果复治涂阳治疗组痰菌阴转率80.0%，对照组65.2%；其中耐多药结核病治疗组痰阴转率61.5%，对照组16.7%。经统计学处理皆有显著性差异 (P＜0.05)。结论治疗组疗效明显优于对照组，化学药物联合免疫调节剂是治疗耐多药结核病及其他难治、复治病例的有效措施。

关键词: 免疫治疗, 结核,肺/药物疗法

Abstract: Objective To observe the curative effect of the retreated pulmonary tuberculosis patients chemotherapy combined with immune regulation preparation.Methods 226 smear-positive cases were divided into trial group and control group at random.All patients were treated by the same chemotherapy regime,but the trial group was assistantly treated by immunotherapy with BCG vaccine polysaccharide nucleic acid (BCG-PSN).The effect was compared between the two groups.Results At the end of the course,the sputum negative conversion rates of the retreated pulmonary tuberculosis of the trial group and the control group were 80.0% and 65.2% respectively.As for MDR pulmonary tuberculosis,the rates were respectively 61.5% and 16.7% for the trial group and the control group.The information above was singnificant in statistics (P＜0.05).Conclusion The curative effect in the trial group was obvious superior to the control group.As indicated the immunotherapy was more effective in treating the retrated pulmonary tuberculosis.

Key words: Immunotherapy, Tuberculosis,pumonary/Drug therapy

冀澍雨,刘瑾,颜鸿飞,张继兴,苏孟,耿凤英,. 化学药物联合免疫调节剂治疗复治肺结核的疗效观察[J]. 中国防痨杂志, 2002, 24(3): 137-139.

JI Shu-yu¹,LIU Jin,YAN Hong-fei,et al.. The therapeutic effect of chemotherapy combined with immunotheraphy on retreated pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2002, 24(3): 137-139.

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