血清抗脂阿拉伯甘露糖及38kD抗体检测对涂阴肺结核及肺外结核诊断价值

中国防痨杂志 ›› 2002, Vol. 24 ›› Issue (3): 140-142.

血清抗脂阿拉伯甘露糖及38kD抗体检测对涂阴肺结核及肺外结核诊断价值

孔忠顺；管波清；古淑香；马玙；

北京市结核病胸部肿瘤研究所北京 101149；

出版日期:2002-03-10 发布日期:2002-11-03

Detection of lipoarabinomannan-38kD-IgG in serum for the diagnosis of pulmonary and extrapulmonary tuberculosis

KONG Zhong-shun,GUAN Bo-qing,GU Shu-xiang,et al.

Beijing Tuberculosis and Thoracic Tumour Research Institute,Beijing 101149

Online:2002-03-10 Published:2002-11-03

摘要/Abstract

摘要： 目的　评估血清抗脂阿拉伯甘露糖及38kDa抗体 (LAM38kD IgG)检测对涂阴肺结核和肺外结核的诊断价值。方法采用斑点免疫金渗滤法 (dotimmunogoldfiltrationassay，DIGFA)检测57例涂阴肺结核，52例肺外结核，32例涂阳肺结核，29例肺癌患者及33例正常人血清中LAM38kD IgG。结果涂阴肺结核组LAM38kD IgG阳性率为73.7%，其中痰结核菌涂 (-)培 (+)组为84 .6%，涂 (-)培 (-)组为70 .5%。肺外结核组阳性率为71.2%，涂 (+)肺结核组阳性率93.8%，肺癌组假阳性率31%，健康组假阳性率9.1%。结论血清LAM38kD IgG检测对涂阴肺结核和肺外结核有一定的辅助诊断价值。

关键词: 结核,肺, 结核,肺外, 脂阿拉伯甘露糖

Abstract: Objective To ascertain the value of lipoarabinomannan-38kD-IgG (LAM-38kD-IgG) determination in the diagnosis of smear negative pulmonary and extrapulmonary tuberculosis.Methods LAM-38kD-IgG in sera obtained from 57 patients with smear negative active pulmonary tuberculosis,52 patients with extrapumonary tuberculosis,32 patients smear positive pulmonary tuberculosis,29 patients with lung cancer and 33 healthy individuals were detected by dot immunogold filtration assay.Results The positive rate was 73.7% in smear negative pulmonary tuberculosis group and the positive rate was 71.2% in extrapulmonary tuberculosis group.The false positive rate was 31.0% in lung cancer group and 9.1% in healthy individuals group.Conclusion The Results suggested that the LAM-38kD-IgG detection was a useful supplementary tool for the diagnosis of smear negative pulmonary tuberculosis and extrapulmonary tuberculosis.

Key words: Tuberculosis,pulmonary, Tuberculosis,extrapulmonary, Lipoarabinomannan-38kD

孔忠顺,管波清,古淑香,马玙,. 血清抗脂阿拉伯甘露糖及38kD抗体检测对涂阴肺结核及肺外结核诊断价值[J]. 中国防痨杂志, 2002, 24(3): 140-142.

KONG Zhong-shun,GUAN Bo-qing,GU Shu-xiang,et al.. Detection of lipoarabinomannan-38kD-IgG in serum for the diagnosis of pulmonary and extrapulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2002, 24(3): 140-142.