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中国防痨杂志 ›› 2018, Vol. 40 ›› Issue (8): 791-795.doi: 10.3969/j.issn.1000-6621.2018.08.003

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  1. 100730 北京,中国医学科学院病原生物学研究所
  • 收稿日期:2018-05-11 出版日期:2018-08-10 发布日期:2018-09-09
  • 通信作者: 高磊

Management of latent tuberculosis infection: moving forward to prevention first

Lei GAO(),Qi. JIN   

  1. Institute of Pathogen Biology of Chinese Academy of Medical Sciences, Beijing 100730,China
  • Received:2018-05-11 Online:2018-08-10 Published:2018-09-09
  • Contact: Lei GAO



关键词: 分枝杆菌, 结核, 感染控制, 干预性研究, 预防性治疗, 潜伏感染


It was estimated that about a quarter of the global population were latently infected with Mycobacterium tuberculosis, and millions of active tuberculosis (TB) diseases will occur from this reservoir. World Health Organization released guidelines in 2015 and in 2018 respectively, to provide updated consolidated guidance for expanding latent tuberculosis infection (LTBI) management in high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100000 population (including China). The development of the national guidelines should adapt to local epidemiology of TB, the availability of resources, and other determinants. Identifying at-risk populations, exploring appropriate intervention tools, and establishing systematic management system all require technical supports by means of strengthening basic research and clinical research. LTBI management is one of the important tools for moving TB control forward to prevention first.

Key words: Mycobacterium tuberculosis, Infection control, Intervention studies, Preventive treatment, Latent infection