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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (2): 187-192.doi: 10.19982/j.issn.1000-6621.20210554

• 论著 • 上一篇    下一篇

2011—2020年广东省佛山市利福平耐药结核病流行特征分析

王威1, 叶一农1, 林东子1, 钟倩红1, 黄飞2, 杜芳芳3, 成诗明3, 周杰4, 张锡林1(), 钟球3()   

  1. 1广东省佛山市第四人民医院,佛山 528041
    2中国国家卫健委-盖茨基金会结核病防治合作项目管理办公室,北京 100050
    3中国防痨协会,北京 100710
    4广东省佛山市中医院,佛山 528099
  • 收稿日期:2021-09-16 出版日期:2022-02-10 发布日期:2022-02-14
  • 通信作者: 张锡林,钟球 E-mail:zhangxlsn@163.com;zhongqiu@vip.163.com
  • 基金资助:
    广东省自然科学基金(2019B1515120067);佛山市第四医院“登峰计划”高水平医院建设开放基金(FSSYDFKF-2020022);广东省医学科研基金(A2015414);佛山市科技创新项目(FS0AA-KJ218-1301-0035);佛山市自筹经费类科技计划项目(医学类科技攻关)(2020001005263)

Analysis of epidemiological characteristics of rifampicin resistance tuberculosis in Foshan City, Guangdong Province, 2011-2020

WANG Wei1, YE Yi-nong1, LIN Dong-zi1, ZHONG Qian-hong1, HUANG Fei2, DU Fang-fang3, CHENG Shi-ming3, ZHOU Jie4, ZHANG Xi-lin1(), ZHONG Qiu3()   

  1. 1Foshan Fourth People’s Hospital, Guangdong Province, Foshan 528041, China
    2China NHC-Gates Foundation TB Project National Program Management Office, Beijing 100050, China
    3Chinese Antituberculosis Association, Beijing 100710, China
    4Foshan Hospital of TCM, Guangdong Province, Foshan 528099, China
  • Received:2021-09-16 Online:2022-02-10 Published:2022-02-14
  • Contact: ZHANG Xi-lin,ZHONG Qiu E-mail:zhangxlsn@163.com;zhongqiu@vip.163.com
  • Supported by:
    Guangdong Basic and Applied Basic Research Foundation(2019B1515120067);“Dengfeng Plan” High-level Hospital Construction Opening Project of Foshan Fourth People’s Hospital(FSSYDFKF-2020022);Medical Scientific Research Foundation of Guangdong Province(A2015414);Foshan Science and Technology Innovation Project(FS0AA-KJ218-1301-0035);Foshan Self Funded Science and Technology Plan Project(2020001005263)

摘要:

目的: 通过结核病常规监测数据分析佛山市利福平耐药结核病流行特征,为制定利福平耐药结核病防控策略提供参考依据。方法: 对佛山市2011—2020年《结核病信息管理系统》中登记的普通肺结核患者、耐药可疑者和耐药患者病案进行清洗和整合,建立耐药结核病特征分析综合数据库。通过对各年份不同来源病原学阳性肺结核患者的耐药筛查情况、菌型鉴定结果和耐药检出情况进行分析,比较不同年份的变化趋势。结果: 佛山市2011—2020年登记病原学阳性肺结核患者中,病原学阳性率由2011年34.0%(1629/4788)增加至2020年56.7%(1505/2655),年均递增率为5.8%。耐药筛查率总体呈现逐年上升的趋势,至2020年本年登记病原学阳性患者耐药筛查率达到100.0%(1505/1505)。2011—2020年期间本年登记初治患者、复治患者和往年登记患者利福平耐药率分别为1.9%(95%CI:1.7%~2.1%)、18.9%(95%CI:17.6%~20.3%)和24.4%(95%CI:23.1%~25.8%);本年登记初治患者利福平耐药率一直维持在比较低的水平,复治患者利福平耐药率由2019年的14.6%(13/89)下降到2020年的2.9%(2/69)。结论: 佛山市常规结核病监测数据能够反映本市的利福平耐药结核病疫情现状,往年登记肺结核患者是下一步耐药结核病防控的重点。

关键词: 结核,肺, 抗药性, 利福平, 流行病学研究

Abstract:

Objective: To analyze the epidemiological characteristics of rifampicin drug-resistant tuberculosis in Foshan City through the routine surveillance data, and then provide a reference for formulating control and prevention strategies. Methods: The medical records of general tuberculosis patients, suspected drug-resistant and drug-resistant patients in the Tuberculosis Information Management System of Foshan City from 2011 to 2020 were cleaned and compiled to establish a comprehensive database. Drug resistance screening, pathogen identification and drug resistance detection were analyzed in different years from different sources, and the trend of resistance in different years was compared. Results: Among the registered pathogenic positive pulmonary tuberculosis patients in Foshan from 2011 to 2020, the pathogenic positive rate increased from 34.0% (1629/4788) in 2011 to 56.7% (1505/2655) in 2020, with an average annual increase rate of 5.8%. The overall drug resistance screening rate shows an upward trend year by year. By 2020, the drug resistance screening rate of registered pathogenic positive patients had reached 100.0% (1505/1505). From 2011 to 2020, the rifampicin resistance rates of newly treated patients, retreated patients and patients registered in previous years were 1.9% (95%CI: 1.7%-2.1%), 18.9% (95%CI: 17.6%-20.3%) and 24.4% (95%CI: 23.1%-25.8%) respectively. The rifampicin resistance rate of newly treated patients registered in the current year had been maintained at a relatively low level, and the rifampicin resistance rate of retreated patients had decreased from 14.6% (13/89) in 2019 to 2.9% (2/69) in 2020. Conclusion: Routine tuberculosis surveillance data can reflect the epidemic situation of rifampin resistant tuberculosis in Foshan city. The registration of tuberculosis patients in previous years is the focus of the next step in the prevention and control of drug-resistant tuberculosis.

Key words: Tuberculosis,pulmonary, Drug resistance, Rifampin, Epidemiologic studies

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