Table of Content

10 March 2003, Volume 25 Issue 3

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The effects of interferon-gamma on immunocompromised mice infected with Mycobacterium tuberculosis

ZHANG Tian-tuo,ZHOU Yu-qi,BI Xiao-gang,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  132-135. 

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Objective To study the effects of IFN-γ on immunocompromised mice infected withMycobacterium tuberculosis.Methods 90 DBA/2 mice infected withMycobacterium tuberculosis were divided randomly into normal control groups and immunocompromised groups, treated with anti-IFN-γ MoAb or IFN-γ respectively. The numbers of viable bacteria in lung were counted. Survival rate after treatment was investigated.Results In control group, none was dead. The numbers of viable bacteria after infection for 14 and 28 days were (51.5±17.5)×10³ cfu/mL,(106.3±41.0)×10³ cfu/mL respectively.In immunocompromised groups, 8 mice were dead. The numbers of viable bacteria were (163.7±61.7)×10³ cfu/mL,(768.3±206.5)×10³ cfu/mL respectively.In immunocompromised treated with IFN-γ group, 3 mice were dead. The numbers of viable bacteria were(54.2±21.3)×10³ cfu/mL,(212.7±80.7)×10³ cfu/mL respectively. There was significant difference between treated and nontreated in immunocompromised. The numbers of viable bacteria in lung were increased in normal mice after treated with anti-IFN-γ MoAb, significant higher than that in the nontreated group.Conclusion IFN-γ improved the host’s immunological function,protected the mice against Mycobacterium tuberculosis infection. It can be used as an adjuvant therapy to immunocompromised host with Mycobacterium tuberculosis.

Anterior radical debridement and interbody fusion with cervical plating in treatment of cervical tuberculosis

CHEN Xing,MA Yuan-zheng,XUE Hai-bin,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  136-139. 

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Objective To evaluate the clinical effectiveness of anterior radical debridement and interbody fusion with cervical plating procedure for treating cervical tuberculosis.Methods From March 1997 to May 2001,anterior radical debridement and interbody fusion with cervical plating procedure were used in 27 patients suffering from cervical spinal tuberculosis,18 of them were involved in a longitudinal study follow-up for a mean of 3.6 years postoperatively.Results All patients achieved satisfactory results, and showed successful interbody fusion. Among 7 cases with neurologic deficit, 2 patients with Frankel’s grade B or C neurologic deficit were improved to Frankel’s grade D, the others were completely recovered. The kyphosis were corrected and the normal cervical lordosis were maintained in 17 patients,1 patient had a unsatisfied lordotic curve resulting from insufficient traction during operation. No notable loss of correction were observed in the final follow-up. There were no plates and screws complications.Conclusion Anterior radical debridement and interbody fusion with cervical plating fixation is effective in strengthening the stability of the spine in cervical tuberculosis and providing successful interbody fusion and early rehabilitation. This procedure is also found helpful in correcting of kyphosis and restoring the normal cervical lordosis.

Analyzed 11 cases of the acute liver failure caused by antitubercular drugs

CAI Xiong-mao,YAO Si-min,FU xiang-dong,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  140-142. 

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Objective To discuss the effect on liver failure caused by antitubercular drugs.Methods The 11 cases of acute liver failure ended death (death group) and 22 cases of severe liver function damage ended recovery (recovery group),both caused by antitubercular drugs,were analyses.Results The age, positive rate of HBsAg, the TBIL level and the time from the emergence of hepatitis symptom to the treatment of drug hepatitis in the death groups is significantly larger or higher or longer than those of recovery group (P<0.05).But the difference of ALT and AST level and the copies of HBV DNA level is not significant. The development of acute fulminant liver failure ended death was related to the following factors: aged patients, HBV infection before treatment, severe jaundice, ignorance and delayed treatment of liver function damage.Conclusion These cases of liver failure the need for stricter adherence to current guidelines on liver function tests after starting anti-tuberculous therapies. TBIL level and prothrombin activity (PTA) is more important indicators than ALT/AST in prognosis. Liver function damage with mainly abnormal ALT/AST and without elevated TBIL level can be recovered by stop using RFP and PZA plus administration of protective liver therapy.

Diagnostic value of rapid culture for Mycobacterium tuberculosis in BALF in atypical pulmonary tuberculosis

PENG Xun ¹,CHANG Zhan-ping,WANG Xiao-qin,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  143-145. 

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Objective To evaluate the diagnostic significance of rapid culture for Mycobacterium tuberculosis in bronchoalveolar lavage fluid (BALF) for atypical pulmonary tuberculosis.Methods Bronchial brushing,and rapid culture for Mycobacterium tuberculosis were performed for 49 cases with atypical pulmonary tuberculosis who had no sputum or negative sputum acid-fast staining,of them 15 cases underwent transbronchial lung biopsy.Results Of the 49 cases,67.4%(33/49) were confirmed by bronchial brushing,83.7% (42/49) were confirmed by rapid culture for Mycobacterium tuberculosis in BALF.Among the 15 cases who underwent transbronchial lung biopsy,pulmonary tuberculosis was confirmed in 10 cases (66.7%).Conclusion Rapid culture for Mycobacterium tuberculosis in BALF is of significant value for the diagnosis of atypical pulmonary tuberculosis with no sputum or negative sputum acid-fast staining.

Analysis of susceptibility testing for 110 strains of Mycobacterium tuberculosis to quinolones

LI Li,XIA Jun-di,ZHANG Wen-hua,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  146-148. 

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Objective To analyze the drug susceptibility testing for 110 strains of M.tuberculosis to quinolones.Methods The drug susceptibility testing (DST) was performed by the tube doubling dilution method, and reformed L-J medium was used.Results The resistance rates of 49 cases with newly diagnosed pulmonary tuberculosis were CPLX 4%, OFLX 8%, LVFX 2% and SPFX 6% . The resistance rates to CPLX, OFLX, LVFX and in the 52 cases with MDR-TB were 52%, 44%, 22%, and 10% respectively , The total resistance rate of 110 strains of MTB were CPLX 26.2%, OFLX 24.7%, LVFX 10.5% and SPLX 7.2%, The cross resistance rate was 23.6%. Conclusion 1.Avoid to give the quinolones as anti-in flammatory treatment on newly diagnosed cases with pulmonary tuberculosis;2.Only use reasonable chemotherapy regimens for the retreated cases with pulmonary tuberculosis;3.To give the full dosage and must complete the full course of treatment with the quinolones;4.The drug susceptibility test to quinolones as the routine assay is necessary.

MRI and CT image diagnosis compared study in tuberculosis meningitis

ZHANG Jin-fu¹,CHEN Hui,XIE Ru-ming,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  149-152. 

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Objective To analyze the features of MRI and CT of tuberculosis meningitis and compare the value of the diagnosis of meningitis with MRI and CT.Methods MRI and CT were formed on 42 patients with tuberculosis meningitis.There were 22 men and 20 women,the age ranging from 16 to 45 year old (mean 25 year).All patients were diagnosed clinically.In pre contrast MRI examination,SE T1,T2 weighted images was chose.Post contrast MRI examination was performed using the same SE T1 sequence as the per contrast MRI imaging .CT was performed with plain scans and contrast-enhanced scans.Results Compared with CT, MRI can revel early abnormality of tuberculosis meningitis and display enshrouded places where abnormal signs cannot be viewed distinctly in CT. MRI also can reliably evaluate prognosis and effect treat.Conclusion Compared with CT,MRI can improve diagnostic accuracy of the tuberculosis meningitis and evaluate exactly curative effect.

The SCL-90 mental state investigate and intervene in the sailors with tuberculosis

CHEN Qing-hua¹,ZHANG Jin-liang,LI Yan-xiang.

Chinese Journal of Antituberculosis. 2003, 25(3):  153-155. 

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Objective To study the mental state of the sailors with tuberculosis.Methods Assess symptoms in 178 cases sailors with tuberculosis used SCL-90.Results 75.8% of the tuberculosis had diversified mental state problem.The scoring was high diversity compared somatization human relation sensitivity,depression,crankiness,anxiety and psychosis with adult model,and had no diversity in hostility,compulsion and phobia.Conclusion The sailors with tuberculosis had mental problem with somatization,human relations sensitivity,depression,crankiness,anxiety and psychosis,and must be aroused recognition and mental intervened earlier.

Analysis on the epidemic situation of tuberculosis in Guangdong province

CHEN Qi-liang,ZHONG Qiu,HUANG Gui-qing,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  156-159. 

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Objective To explore the Methods for tuberculosis control in Guangdong province.Methods To analyze the epidemic situation of tuberculosis using the Results of the last three epidemiologic sampling survey for tuberculosis and the data from tuberculosis control project loaned by the World Bank.Results The prevalence of active and smear positive tuberculosis were 862.87/100?000 and 232.89/100?000 respectively in 1979,493.43/100?000 and 111.84/100?000 respectively in 1990,351.74/100?000 and 106.75/100?000 in 2000.The notification rates of active tuberculosis and smear positive tuberculosis raised during the tuberculosis control project,that implementing from 1992.The cure rate of smear positive tuberculosis also increased up to 85% during the project.Conclusion The tuberculosis prevalence decreased significantly.In order to control tuberculosis,the most important Methods are to implement the modern tuberculosis control strategies (DOTS),to improve the detection and management for tuberculosis in the floating population,and to limite the production of MDR-TB cases.

Analyse influencing factors about finding of smear-positive pulmonary tuberculosis case in Ningxia

LI Jie,ZHU Gui-lin,ZHAO Xiao,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  160-162. 

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Objective To study mainly influencing factors about case-finding of smear-positive pulmonary tuberculosis in Ningxia and to enhance the case-finding lever.Methods The registration report of 6 cities has been analyzed.The condition of transferring about the smear-positive cases in 1999,2000 and 2001 have been investigated. At the same time, the information about pulmonary tuberculosis prevents and cure through questionnaire year has been analyzed.Results The registration rate of the smear-positive pulmonary tuberculosis was under average lever of World Bank Loan Tuberculosis Control project province in the same term. The registration rate of the smear-positive pulmonary tuberculosis was showed positive correlation with the product of three factors which were the rate of suspect see a doctor, the rate of sputum examination and the rate of smear positive. But it did not show correlation with any one factor among three factors.Conclusion Three factors are mainly influencing factors about the case-finding of the smear-positive pulmonary tuberculosis.If three factors rise together,the finding rate of the smear-positive pulmonary tuberculosis will rise.

Investigation analysis on 531 TB children admitted

Li Xiang-hua,Li Hai-quan,Xia Dong,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  163-164. 

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Objective To evaluate the effect of the prevention and treatment for 531 TB children admitted in the past 25 years.Methods The TB cases on the TB children admitted were investigated and analysed.Results 531 TB children had been treated.There were 297 cases with primary pulmonary tuberculosis and tuberculous meningitis,which were 55.9% of the total TB children.The mortality was decreased from 3.6% to 0.Conclusion The morbidity primary pulmonary tuberculsis children admitted was decreased evidently for the work of BCG vaccine inoculation to new-born infants and the prevention and control of tuberculosis in the city of Daqing was performed in depth.

Instance and effect of the implement of controlling the tuberculosis in Haiyan county in the period 1996-2000

Zhang Li-gen,SHEN Zhu-ming, Xu Pei-hua.

Chinese Journal of Antituberculosis. 2003, 25(3):  165-167. 

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Objective To report the instance and effect of the implement of controlling the tuberculosis in Haiyan county in the period 1996-2000.Methods To evalute the prevention and cure according to laws,the centralized management measure,the criterion,the control of the quality of examining sputum and supervising of chemotherapy in the period 1996-2000.Results 339 sputum smear-positive tuberculosis patients were found in the period 1996-2000.Sputum examination rate of new patients was keeping 95%. The detection rate of smear positive patients was 45.0%. The finding rate of smear positive increased from 17.99/10⁵to 23.57/10⁵. The cure rate of smear positive patients increased from 90.91% to 93.33%.Conclusion The finding of infectious cases and the cure rate are improved,the infectious sources were effectually control.It is the important to increase the case-finding rate and improve the quality of the DOTS.

Analysis of the effect of TB control project loaned by World Bank in Boluo county (1993～2000)

MEI Yue-zhi.

Chinese Journal of Antituberculosis. 2003, 25(3):  168-170. 

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Objective Analyze the effects of TB control project loaned by World Bank in Boluo County (1993—2000).Methods To analyze the treatment effect of the TB patients according to Boluo county annual report from 1993 to 2000.Results Over the past 8 years,5773 cases suspected of pulmonry tuberculosis have been received and diagnosed,the cure rate for initial smear-positive treated cases was 95.9% and 86.9% for retreated cases.Conclusion Satisfactory Results have been achieved of TB control project loaned by World Bank in Boluo.

Analysis on tuberculosis interfering of health-Ⅷ project in the poor areas in Henan province

MA Li-ping, ZHANG Yan-qiu,CHENG Zhe.

Chinese Journal of Antituberculosis. 2003, 25(3):  171-174. 

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Objective To analyze the affecting factors and effect of tuberculosis interfering in the poor rural areas in Henan.Methods 1.Establishing and strengthening anti-tuberculosis networks from county to village level. 2.Making it standardization that the management procedure of DOTS. 3. Providing free treatment to communicable tuberculosis patients and serious smear negative cases. 4. Conducting trails in some townships at the beginning, and then extending it after summarizing.Results The cure rate for initial and retreatment smear positive cases is 86.7% and 66.4%, respectively. And the DOTS rate is 71.4%.Conclusion By the implementation of health-Ⅷ project, it is improved obviously that the working condition for the anti-tuberculosis staff. And the technical competence of technicians increased gradually. Also, the cure rate for tuberculosis cases increased.

The situation of resistance to Anti-TB drugs among in-patients in Shandong provincial thoracic hospital

QIU Li-hua,ZHAI Ou,WANG Xue-dong,et al.

Chinese Journal of Antituberculosis. 2003, 25(3):  175-177. 

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Objective To investigate resistant situation to anti-TB drugs among in-patients with pulmonary TB in Shandong Thoracic Hospital and the difference of drug resistance among patients from cities,towns and rural area and patients floating to cities.Methods Analysis was conducted on laboratory data concerning Mycobacterial type identification tests and drug resistant tests to INH,SM,RFPand EMB for patients with sputum culture positive pulmonary TB hospitalized in our hospital from 1991 to December 2000.Results The total initial drug resistance rate was 17.7%,9.5%,13.6%,15.2% and 23.6% respectively for patients from cities,towns,other parts floating to cites and rural area. The total acquired drug resistance rate was 85.4%,77.6%,83.9%,87.5% and 89.1% respectively for patients from cites,towns, other parts floating to cites and rural area.Conclusion Resistance to Anti-TB drugs was the highest among rural inpatients of our hospital,and then,the in-patients floating to cites,from towns and cites.

Analysis for treatment effect of new smear-positive pulmonary tuberculosis in Huizhou city

ZHANG Yuan-sen.

Chinese Journal of Antituberculosis. 2003, 25(3):  178-180. 

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Objective To analyze the treatment effect of smear-positive cases wiht pulmonary tuberculosis.Methods smear-positive pulmonary tuberculosis were treated with the short-course chemotherapy regimens,and were confirmed the effectiveness after finishing the treatment. Results The cured rate of 728 cases initial treatment of smear-positive pulmonary tuberculosis was 97.7%,and the cured rate of 159 cases retreatment of smear-positive pulmonary tuberculosis was 90.6%. Conclusion In order to improve the effectiveness of the chemotherapy, optimum chemotherapy regimens must be adopted and DOTS must be implemented.

The effect analysis of tuberculosis control project of health V in Maoming city

ZHU Xing-ming,HUANG Xiang-shui,WU Guang-wei,el al.

Chinese Journal of Antituberculosis. 2003, 25(3):  181-183. 

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Objective To analyza efficacy of society and economic in procedure of the tuberculosis control project of heath V.Methods Relevant policy of the project and tuberculosis knowledge have been spreaded by variety medium and special transfer management for suspicious tuberculosis patients have been strengthen in general hospital and town hospital.then,according to the management pattern of the project,organize and carry out the work of case finding,treating and managing.Results 16664 cases of active pulmonary tuberculosis have been diagnosed in Mao ming city.in which,12itive pulmonary tuberculosis and 1892 case of other smear positive pulmonary tuberculosis have been founded.The new smear positive cure rate showed amounting from 42.9% of before the project to 96.2% among the project.The retreatment smear positive cure rate showed amounting form 55.5% of before the project to 82.4% among the project.Conclusion The modern tuberculosis control strategy,which mainly targeted infectious patient and advocated DOTS policy and legal administration for procedure of the transfer are the guarantee of sustainably development of tuberculosis control

Analysis for the effect of TB control project implementing in Nanhai City of Guangdong province

ZENG Yun-fan.

Chinese Journal of Antituberculosis. 2003, 25(3):  184-187. 

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Objective To evaluate the outcome of the TB control project loaned by the World Bank in Nanhai city.Methods The patients who consulted clinic for symptom were screened by the way of X-ray examination. TB patients were confirmed by sputum examination and treated using unified chemo-therapy regimen. And the management of DOTS were implemented.Results During the decade, 19569 cases of TB suspected patient were screened, and the detected rate was 0.2%. There were 4286 cases of active TB confirmed. Among them, 2558 cases are sputum smear positive and account for 59.7% of the active TB. The notification rate of smear positive TB increased from 14.07/100,000 to 35.66/100,000. The ratio of initial treatment cases with smear positive and re-treatment is 1 to 0.14. The cured rate of the initial treatment cases is 94.3% and the re-treatment cases is 82.2%. The benefit of case-finding and treatment management reached 3 times than before.Conclusion In the past 10 years, the level for TB control has been raised completely.

Analysis on the effect of the tuberculosis control project in Feshan City(1992-2001)

ZHANG Ming,YE Nian-cheng.

Chinese Journal of Antituberculosis. 2003, 25(3):  188-192. 

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Objective To analyze the effect of the TB control project in Feshan City.Methods Collecting and analyzing the data of the tuberculosis control project loaned by the world bank in Feshan City from 1992 to 2001.Results there were 40470 suspects examined and 8652 cases with active tuberculosis discovered. In the cases, there were 5005 pulmonary tuberculosis with smear-positive, 4320 new cases with smear-positive, and 685 retreatment cases with smear-positive. The notification rate of new smear-positive cases is 7.47/100000 in 1993, up to 30.30/100000 in 2001. The cured rate of initial treatment cases rises to 99.4% from 73.5% from 1993 to 2001. And the retreatment smear-positive cases rises to 91.4% from 60.8% from 1993 to 2001.Conclusion In the decade, The TB control project in Feshan City has achieved the target of “high rate of discovery” and “high rate of successful treatment” and has improved. It is because that free examination was provided the case-management was converged and the strategy of DOTS was implemented. It is a good experience for new project implementing in Guangdong province. Develop the work of TB control in Feshan City.