Research progress on animal model of Brucella spondylitis

doi:10.19982/j.issn.1000-6621.20230163

Abstract

Abstract:

Brucellosis is a zoonotic disease caused by Brucella. Brucella concentrated in the local erosion of spine vertebrae and other tissues causes low back pain and other related symptoms, that is, Brucella spondylitis (BS). In recent years, the incidence of BS increased, and missed diagnosis and misdiagnosis occurred from time to time. The pathogenesis of BS is complex, and it has not been accurately identified at present, so the preclinical experiment is particularly important. Animal model is an important way of basic research, and appropriate model research could provide guidance to clinicians for disease treatment. BS is rather complex, and the establishment of animal model is relatively difficult. In this paper, the established animal models are analyzed and discussed in order to provide reference for subsequent animal model research.

Key words: Brucellosis, Spondylitis, Disease models,animal, Review literature as topic

CLC Number:

R516.7

Li Yiqi, Liu Yongming, Chen Yaolong, Yang Yinjun, Liu Bei, Wen Fayan, Li Yan. Research progress on animal model of Brucella spondylitis[J]. Chinese Journal of Antituberculosis, 2023, 45(9): 913-920. doi: 10.19982/j.issn.1000-6621.20230163

Figures/Tables 6

References 49

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实验动物	造模标准	优点	缺点
小鼠	临床症状、生物发光成像、病理组织切片	成熟较快,遗传背景清楚,价格低廉,易获得	基因敲除后丧失免疫作用,无明显临床症状,病亡率较高,多用于急性布鲁氏菌病研究
兔子	影像学检查、病理组织切片	腰椎解剖结构、病理表现类似人类,易行手术暴露直接感染	难以检测病变时间,缺乏免疫试剂,存在易感性
犬	临床症状、影像学检查、细菌培养	自然状态下感染,出现类似人类感染症状	难以获得,多涉及伦理问题