Overview of genomic research on Mycobacteriophages

doi:10.19982/j.issn.1000-6621.20240217

Abstract

Abstract:

Mycobacterial infections represent a significant global health burden, with multidrug-resistant tuberculosis (MDR-TB) posing a critical public health crisis and a serious threat to health security. Identifying effective strategies to combat mycobacterial infections has become an urgent priority. Mycobacteriophages, viruses that specifically target and lyse mycobacteria, offer a promising approach by effectively killing the host bacteria. litating the advancement of mycobacteriophage applications. This review explores the general genomic characteristics, gene functions, and expression patterns of mycobacteriophages, offering a foundation for further research in this field.

Key words: Mycobacterium infections, Mycobacteriophages, Genomics, Gene expression, Review literature as topic

CLC Number:

Liu Kejun, Zhang Haipeng, Wang Peng. Overview of genomic research on Mycobacteriophages[J]. Chinese Journal of Antituberculosis, 2024, 46(10): 1283-1292. doi: 10.19982/j.issn.1000-6621.20240217

Figures/Tables 3

References 63

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簇	亚簇	成员数量	平均长度 (bp)	平均GC %含量	平均基因数量	平均tRNA 基因数量	簇	成员数量	平均长度 (bp)	平均GC %含量	平均基因数量	平均tRNA 基因数量
A	19	770	51603	63.3	90.5	1.2	R	10	71339	56.0	98	0
B	13	415	68822	67.1	98.3	0	S	19	64972	63.4	107	0
C	2	188	155628	64.7	230.5	32.9	T	7	42746	66.2	61	-
D	2	22	64789	59.6	88.8	0	U	3	66864	50.4	104	1
E	0	130	75493	63.0	142.6	1.9	V	5	77907	56.9	145.3	23.3
F	5	237	57338	61.5	104.1	0	W	6	61013	67.5	-	-
G	5	70	42363	66.9	62	0	X	2	88037	56.7	-	-
H	2	12	69127	57.3	98.7	0	Y	4	76836	66.7	-	-
I	2	7	50320	66.4	80.2	0	Z	2	50807	66.0	-	-
J	0	43	111094	60.9	235.3	1.6	AA	2	140785	67.4	-	-
K	8	185	59991	66.8	93.6	0.9	AB	5	49672	58.6	71	0
L	5	76	74381	58.9	124.7	10.3	AC	4	70029	49.8	-	-
M	3	20	81622	61.3	141.3	18.7	AD	4	64670	66.1	93	0
N	0	43	42941	66.2	68.9	0	AE	3	71540	58.8	-	-
O	0	28	71124	65.4	121.1	0	AF	2	62538	65.2	-	-
P	6	49	47839	67.0	79.3	0	AG	2	55047	66.0	-	-
Q	0	22	53835	67.4	81	0	AH	2	54800	70.4	-	-

噬菌体名称	宿主菌	菌种	簇	基因长度(bp)	GC%含量	发现年份	发现地
StAugustine	耻垢分枝杆菌	mc²155	单胞体	101031	65.7	2023	佐治亚州,美国
P3MA	脓肿分枝杆菌	330	单胞体	41234	63.4	2023	未知
MooMoo	耻垢分枝杆菌	mc²155	单胞体	55178	62.0	2011	肯塔基州,美国
LilSpotty	耻垢分枝杆菌	mc²155	单胞体	49798	64.7	2018	加尼福利亚州,美国
Kumao	耻垢分枝杆菌	mc²155	单胞体	70373	62.1	2015	宾夕法尼亚州,美国
IdentityCrisis	耻垢分枝杆菌	mc²155	单胞体	38341	65.0	2018	佛罗里达州,美国
DS6A	结核分枝杆菌	H37Rv	单胞体	60588	68.4	1960	未知
平均	-	-	-	59506	64.5	-	-