The function and mechanism of G protein-coupled receptors in host against Mycobacterium tuberculosis infection

doi:10.19982/j.issn.1000-6621.20240118

Abstract

Abstract:

G protein-coupled receptors (GPCRs) play a critical role in maintaining normal physiological functions and intracellular homeostasis in the human body. Dysregulation of GPCRs and their downstream signaling pathways are significant markers in the development and progression of various diseases. In recent years, the prevention and treatment of tuberculosis (TB) have faced increasingly severe challenges, highlighting the urgent need for the development of new anti-TB drugs that are safe, affordable, and sensitive. Among these, novel antimicrobial drugs based on host-directed therapeutic strategies have garnered widespread attention. GPCRs, as receptors that regulate host immune expression, can serve as potential therapeutic targets for host-directed anti-TB treatment. However, researches on GPCRs as important drug targets in the field of TB are still insufficient. The author summarizes the recently discovered functions of GPCRs in host cell responses to Mycobacterium tuberculosis infection. It systematically reviews the key roles and molecular mechanisms of chemokine receptor-like GPCRs, orphan GPCRs, and other GPCRs in regulating host cell signal transduction, providing a basis for the development of GPCR-based anti-TB drugs.

Key words: Receptors, G-protein-coupled, Macrophages, Mycobacterium tuberculosis, Infection

CLC Number:

R373.5
R392

Liu Haohan, Ma Zichun, Pang Yu, Li Shanshan. The function and mechanism of G protein-coupled receptors in host against Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2024, 46(7): 839-844. doi: 10.19982/j.issn.1000-6621.20240118

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