Implementation update of strategy for the control of tuberculosis and HIV/AIDS co-infection in China

doi:10.19982/j.issn.1000-6621.20240331

Abstract

Abstract:

Tuberculosis (TB) and AIDS are both serious infectious diseases in the world. TB is a commonly opportunistic infection and the major cause of death among HIV/AIDS patients, and meanwhile the HIV/AIDS dramatically increases risk of TB incidence. The TB-HIV/AIDS co-infection mutually exacerbates progression of the diseases, making it a serious threat to public health globally. The author made a review to the prevalence and control strategy of TB-HIV/AIDS co-infection, and proposed the main problems and countermeasures.

Key words: Tuberculosis, HIV infections, Acquired immunodeficiency syndrome, Comorbidity, Protective agents

CLC Number:

R52
R512.91

Zhang Guoqin, Qu Ting, Meng Qinglin, Zhou Lin, Liu Eryong. Implementation update of strategy for the control of tuberculosis and HIV/AIDS co-infection in China[J]. Chinese Journal of Antituberculosis, 2025, 47(1): 12-17. doi: 10.19982/j.issn.1000-6621.20240331

References 44

[1]	World Health Organization. Global tuberculosis report 2024. Geneva: World Health Organization, 2024.
[2]	Jesudason T. Global progress reported for AIDS. Lancet Infect Dis, 2023, 23(9): e342. doi:10.1016/s1473-3099(22)00684-3. URL pmid: 37633298
[3]	韩孟杰. 我国艾滋病流行形势分析和防治展望. 中国艾滋病性病, 2023, 29(3): 247-250. doi:10.13419/j.cnki.aids.2023.03.01.
[4]	潘锋. 我国艾滋病防控工作仍面临多重挑战. 中国当代医药, 2024, 31(11): 1-3. doi:10.3969/j.issn.1674-4721.2024.11.002.
[5]	吴雪韵, 沈银忠. 人类免疫缺陷病毒与结核分枝杆菌合并感染发病机制的研究进展. 内科理论与实践, 2019, 14(4): 253-258. doi:10.16138/j.1673-6087.2019.04.011.
[6]	Toossi Z, Hirsch CS, Wu M, et al. Distinct cytokine and regulatory T cell profile at pleural sites of dual HIV/tuberculosis infection compared to that in the systemic circulation. Clin Exp Immunol, 2011, 163(3): 333-338. doi:10.1111/j.1365-2249.2010.04269.x. URL pmid: 21303360
[7]	李雨薇, 李侠. 艾滋病/结核病双重感染流行现状与研究进展. 中外医学研究, 2022, 20(16): 181-184. doi:10.14033/j.cnki.cfmr.2022.16.046.
[8]	毛琛, 王岚, 李立明. 我国流行病学学科发展70年的历程与成就. 中华流行病学杂志, 2019, 40(10): 1173-1179. doi:10.3760/cma.j.issn.0254-6450.2019.10.001.
[9]	Liu E, Wang Q, Zhang G, et al. Tuberculosis/HIV Coinfection and Treatment Trends-China, 2015—2019. China CDC Wkly, 2020, 2(48): 924-928. doi:10.46234/ccdcw2020.252.
[10]	郑志刚, 耿文奎, 陆珍珍, 等. 艾滋病病毒与结核分枝杆菌双重感染对死亡的影响. 中华流行病学杂志, 2018, 39(10): 1362-1367. doi:10.3760/cma.j.issn.0254-6450.2018.10.014.
[11]	周林, 刘二勇. 国内外Mtb与HIV双重感染防治进展与展望. 中国防痨杂志, 2014, 36(9): 802-805. doi:10.3969/j.issn.1000-6621.2014.09.011.
[12]	World Health Organization. Framework for collaborative action on tuberculosis and comorbidities. Geneva: World Health Organization, 2022.
[13]	World Health Organization. WHO consolidated guidelines on tuberculosis. Module 6: tuberculosis and comorbidities. Geneva: World Health Organization, 2024.
[14]	中华人民共和国卫生部办公厅. 卫生部办公厅关于印发《全国结核菌/艾滋病病毒双重感染防治工作实施方案(试行)》的通知. 卫办疾控发〔2010〕126号. 2010-08-03.
[15]	阮军, 尹恒, 寇国先, 等. 艾滋病合并肺结核259例临床分析. 中国艾滋病性病, 2020, 26(5): 490-492. doi:10.13419/j.cnki.aids.2020.05.09.
[16]	柯柳, 覃绍超, 刘志娟, 等. 艾滋病合并肺结核113例临床及CT影像分析. 中国艾滋病性病, 2020, 26(10): 1103-1105. doi:10.13419/j.cnki.aids.2020.10.19.
[17]	舒伟强, 吕圣秀, 李春华, 等. 艾滋病并发肺结核多层螺旋CT影像特点分析. 临床肺科杂志, 2019, 24(10): 1891-1895. doi:10.3969/j.issn.1009-6663.2019.10.034.
[18]	郑小燕, 马琴, 陈永宏, 等. HIV感染合并肺结核肺影像学CT特征与CD4⁺ T细胞及病毒载量的相关性. 中华医院感染学杂志, 2021, 31(2): 193-197. doi:10.11816/cn.ni.2021-201695.
[19]	刘广天, 刘涛, 王晓炜, 等. 宁夏地区“互联网+医疗”模式在结核病防治工作中的应用. 中国防痨杂志, 2020, 42(7): 676-681. doi:10.3969/j.issn.1000-6621.2020.07.007.
[20]	王晓林, 王晓炜, 雷娟, 等. 宁夏回族自治区肺结核人工智能影像筛查系统的应用. 中国数字医学, 2020, 15(4): 39-41. doi:10.3969/j.issn.1673-7571.2020.04.012.
[21]	王前, 何金戈, 李玉红, 等. 人工智能自动阅片技术用于HIV/AIDS人群结核病主动筛查效果的研究. 中国防痨杂志, 2021, 43(6): 557-561. doi:10.3969/j.issn.1000-6621.2021.06.007.
[22]	Vittor AY, Garland JM, Gilman RH. Molecular Diagnosis of TB in the HIV Positive Population. Ann Glob Health, 2014, 80(6): 476-485. doi:10.1016/j.aogh.2015.01.001. URL pmid: 25960097
[23]	梁小烟, 林玫, 梁大斌, 等. HIV/AIDS合并感染MTB检测技术的研究进展//中国防痨协会第33届全国学术大会暨中国防痨科技奖颁奖大会论文汇编. 青岛: 2021. doi:10.26914/c.cnkihy.2021.046827.
[24]	袁婧, 刘俊, 金永梅, 等. 合并艾滋病的结核病患者血液结核分枝杆菌培养阳性率影响因素的分析. 临床肺科杂志, 2018, 23(7): 1175-1178. doi:10.3969/j.issn.1009-6663.2018.07.004.
[25]	谢志满, 兰江, 卢祥婵, 等. 996例HIV感染者PPD试验结果分析. 医学动物防制, 2014, 30(12): 1305-1307. doi:10.7629/yxdwfz201412003.
[26]	Ma Y, Xu Y, Cao X, et al. Diagnostic value of interferon-γ release assay in HIV-infected individuals complicated with active tuberculosis: a systematic review and meta-analysis. Epidemiol Infect, 2021, 149:e204. doi:10.1017/s0950268821 001953.
[27]	沈鑫, 沈银忠, 刘二勇, 等. 结核分枝杆菌和人类免疫缺陷病毒感染双向筛查技术应用专家共识. 上海预防医学, 2024, 36(4): 327-336. doi:10.19428/j.cnki.sjpm.2024.23523.
[28]	中国性病艾滋病防治协会HIV合并结核病专业委员会. 人类免疫缺陷病毒感染/艾滋病合并结核分枝杆菌感染诊治专家共识. 新发传染病电子杂志, 2022, 7(1): 73-87. doi:10.19871/j.cnki.xfcrbzz.2022.01.017.
[29]	唐明慧, 李浩. 脂阿拉伯甘露聚糖的结构功能及其在结核病诊断中的应用. 中国防痨杂志, 2022, 44(11): 1205-1212. doi:10.19982/j.issn.1000-6621.20220276.
[30]	European AIDS Clinical Society. EACS Guidelines (Version 12.0)[EB/OL]. [2024-07-28]. https://www.eacsociety.org/media/guidelines-12.0.pdf.
[31]	Ahmed Mustafa GM, Yassin ME, Shami A, et al. Screening of Human Immunodeficiency Virus (HIV) among Newly Diagnosed Tuberculosis Patients in Eastern Sudan. Pol J Microbiol, 2021, 70(2): 201-206. doi:10.33073/pjm-2021-017. URL pmid: 34349811
[32]	赵雁林, 陈明亭. 中国结核病防治工作技术指南. 北京: 人民卫生出版社, 2021.
[33]	Nglazi MD, Bekker LG, Wood R, et al. The impact of HIV status and antiretroviral treatment on TB treatment outcomes of new tuberculosis patients attending co-located TB and ART services in South Africa: a retrospective cohort study. BMC Infect Dis, 2015, 15: 536. doi:10.1186/s12879-015-1275-3. URL pmid: 26584607
[34]	Abdool Karim SS, Naidoo K, Grobler A, et al. Timing of initiation of antiretroviral drugs during tuberculosis therapy. N Engl J Med, 2010, 362(8): 697-706. doi:10.1056/NEJMoa0905848.
[35]	许静, 郑全庆, 张天华, 等. 陕西省TB与HIV/AIDS双向筛查及TB/HIV患者抗结核治疗转归队列分析. 中国热带医学, 2018, 18(6): 619-623. doi:10.13604/j.cnki.46-1064/r.2018.06.27.
[36]	许琳, 杨蕊, 高小娇, 等. 结核病/艾滋病双重感染患者抗结核治疗生存分析. 现代预防医学, 2015, 42(19): 3587-3589, 3605.
[37]	UNAIDS. The Path That Ends AlDS 2023 Unaids Global Aids Update[EB/OL]. (2023-07-03)[2024-07-28]. https://thepath.unaids.org/.
[38]	中华医学会感染病学分会艾滋病丙型肝炎学组,中国疾病预防控制中心. 中国艾滋病诊疗指南(2021年版). 中国艾滋病性病, 2021, 27(11): 1182-1201. doi:10.13419/j.cnki.aids.2021.11.02.
[39]	Padmapriyadarsini C, Bhavani PK, Tang A, et al. Early changes in hepatic function among HIV-tuberculosis patients treated with nevirapine or efavirenz along with rifampin-based anti-tuberculosis therapy. Int J Infect Dis, 2013, 17(12): e1154-e1159. doi:10.1016/j.ijid.2013.08.006.
[40]	Lawn SD, Churchyard G. Epidemiology of HIV-associated tuberculosis. Curr Opin HIV AIDS, 2009, 4(4): 325-333. doi:10.1097/COH.0b013e32832c7d61. URL pmid: 19532072
[41]	Akolo C, Adetifa I, Shepperd S, et al. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev, 2010, 2010(1): CD000171. doi:10.1002/14651858.CD000171.pub3.
[42]	徐彩虹, 赵雁林. 中国结核病预防性治疗指南. 北京: 人民卫生出版社, 2023.
[43]	UNAIDS. 2024 Global AIDS Update. Geneva: UNAIDS, 2024.
[44]	UNAIDS. Impact of COVID-19 hits hard as TB deaths among people living with HIV rise for the first time since 2006[EB/OL].[2024-07-28]. https://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2022/march/20220323_tb-day.