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中国防痨杂志 ›› 2025, Vol. 47 ›› Issue (2): 123-129.doi: 10.19982/j.issn.1000-6621.20240480

• 指南·规范·共识 • 上一篇    下一篇

康替唑胺治疗结核病专家共识

中国防痨协会《中国防痨杂志》编辑委员会 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所 Inspire⁃CODA研究组   

  • 收稿日期:2024-11-04 出版日期:2025-02-10 发布日期:2025-02-08
  • 通信作者: 初乃惠,Email:chunaihui1994@sina.com;聂文娟,Email:94642975@qq.com;张文宏,Email:zhangwenhong@fudan.edu.cn; 孙峰,Email:aaronsf1125@126.com
  • 基金资助:
    临床医学发展专项“扬帆3.0”计划项目(ZLRK202331);北京市卫生健康委员会研究型病房卓越临床研究计划(BRWEP2024W042160109);广州国家实验室专项-结核病短程治疗方案开发(GZNL2024A01030);国家重点研发项目-结核病早期诊断干预关键技术与耐药结核病治疗体系研究(2024YFC2311200)

Expert consensus on the treatment of tuberculosis with contezolid

Chinese Antituberculosis Association, Editorial Board of Chinese Journal of Antituberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Inspire-CODA Research Group   

  • Received:2024-11-04 Online:2025-02-10 Published:2025-02-08
  • Contact: Chu Naihui, Email: chunaihui1994@sina.com; Nie Wenjuan, Email: 94642975@qq.com; Zhang Wenhong, Email: zhangwenhong@fudan.edu.cn;Sun Feng, Email: aaronsf1125@126.com
  • Supported by:
    Clinical Medicine Development Special Project “Sailing” Plan Project(ZLRK202331);Beijing Municipal Health Commission Research Ward Excellent Clinical Research Program(BRWEP2024W042160109);Special Project of Guangzhou National Laboratory-Development of Shorter Treatment Scheme for tuberculosis(GZNL2024A01030);The National Key Research and Development Project-Research on Key Technologies of Early Diagnosis and Intervention of Tuberculosis and Treatment System of Drug Resistant Tuberculosis(2024YFC2311200)

摘要:

康替唑胺是我国自主研发的新一代噁唑烷酮类药物,已被批准用于治疗细菌引起的复杂性皮肤和软组织感染。随着康替唑胺在结核病治疗临床探索性应用的日益广泛及临床研究的不断拓展,临床医生对其临床应用的指南或规范需求愈发迫切。为此,《中国防痨杂志》编辑委员会和中国防痨协会共同组织全国相关领域的专家进行了深入研讨,并制定了《康替唑胺治疗结核病专家共识》。本共识旨在规范和指导医务工作者在结核病治疗中使用康替唑胺,解决药物说明书或现有的抗结核治疗指南共识中缺乏关于康替唑胺抗结核治疗的适应证、剂量或疗程等问题所带来的困惑。期望本共识能为国内同行提供有益参考,共同推动康替唑胺在临床实践中的合理应用。

关键词: 恶唑烷酮类, 康替唑胺, 抗结核药, 治疗应用, 总结性报告(主题)

Abstract:

Contezolid, a novel generation of oxazolidinone antibiotics independently developed in China, has been approved for the treatment of complex skin and soft tissue infections. With its expanding exploratory applications in the clinical management of tuberculosis and the ongoing growth of related clinical research, there is an increasing demand among clinicians for comprehensive guidelines and standardized protocols for its use. To address this need, the Editorial Board of the Chinese Journal of Antituberculosis and the Chinese Antituberculosis Association convened experts nationwide for in-depth discussions, culminating in the development of the Expert consensus on the treatment of tuberculosis with contezolid. This consensus aims to standardize and guide healthcare professionals in the use of contezolid for tuberculosis treatment, addressing uncertainties arising from the lack of specified indications, dosages, or treatment durations in current drug labels and existing antituberculosis guidelines. It is hoped that this consensus will serve as a valuable reference for practitioners in China and contribute to the rational and effective application of contezolid in clinical practice.

Key words: Oxazolidinones, Contezolid, Antitubercular agents, Therapeutic applications, Consensus guidelines

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