世界卫生组织《应用新一代靶向测序技术检测耐药结核病:快速通告,2023》解读

doi:10.19982/j.issn.1000-6621.20230311

中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (10): 921-924.doi: 10.19982/j.issn.1000-6621.20230311

世界卫生组织《应用新一代靶向测序技术检测耐药结核病:快速通告,2023》解读

黄海荣()

首都医科大学附属北京胸科医院国家结核病临床实验室,北京 101149

收稿日期:2023-08-28 出版日期:2023-10-10 发布日期:2023-10-07
通信作者: 黄海荣,Email:huanghairong@tb123.org
基金资助:
北京市卫生健康委员会高层次公共卫生人才项目(G2023-2-002)

Interpretation of the World Health Organization's Use of targeted next-generation sequencing to detect drug-resistant tuberculosis Rapid communication, 2023

Huang Hairong()

National Clinical Laboratory on Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China

Received:2023-08-28 Online:2023-10-10 Published:2023-10-07
Contact: Huang Hairong, Email: huanghairong@tb123.org
Supported by:
Beijing Municipal Health Commission High Level Public Health Talent Project(G2023-2-002)

摘要/Abstract

摘要：

世界卫生组织近期发布了《应用新一代靶向测序技术检测耐药结核病:快速通告,2023》,目的是向全球及时分享关于新一代靶向测序技术在耐药结核病应用情况的重要数据,以及据此形成的主要观点,从而推动该技术的合理应用和推广。本文对该通告中的重要数据和观点进行了解读,以便读者了解新一代靶向测序技术对耐药结核病诊断的价值。

关键词: 分枝杆菌,结核, 抗药性,细菌, 诊断技术和方法, 基因,细菌, 总结性报告(主题)

Abstract:

The World Health Organization released “Use of targeted next-generation sequencing to detect drug-resistant tuberculosis Rapid communication,2023” recently, in order to timely share the important data and opinions formed accordingly on drug resistance detection by the targeted next-generation sequencing technique. Therefore, facilitate the understanding of this new technique and accelerate its promotion. This note interpreted the key data and the opinions in the rapid communication, so as to help the reader to recognize the value of the targeted next-generation sequencing technique in the diagnosis of drug resistant tuberculosis.

Key words: Mycobacterium tuberculosis, Drug resistance, bacterial, Diagnostic techniques and procedures, Genes, bacterial, Consensus development conferences as topic

中图分类号:

R52
R825.2

黄海荣. 世界卫生组织《应用新一代靶向测序技术检测耐药结核病:快速通告,2023》解读[J]. 中国防痨杂志, 2023, 45(10): 921-924. doi: 10.19982/j.issn.1000-6621.20230311

Huang Hairong. Interpretation of the World Health Organization's Use of targeted next-generation sequencing to detect drug-resistant tuberculosis Rapid communication, 2023[J]. Chinese Journal of Antituberculosis, 2023, 45(10): 921-924. doi: 10.19982/j.issn.1000-6621.20230311

参考文献 12

[1]	高通量测序共识专家组. 高通量测序技术在分枝杆菌病诊断中的应用专家共识. 中华传染病杂志, 2023, 41(3):175-182. doi:10.3760/cma.j.cn311365-20221203-00492.
[2]	World Health Organization. Use of targeted next-generation sequencing to detect drug-resistant tuberculosis Rapid communication, 2023. Geneva: Word Health Organization, 2023.
[3]	World Health Organization. WHO consolidated guidelines on tuberculosis. Module 3: diagnosis-rapid diagnostics for tuberculosis detection, 2021 update. Geneva: World Health Organi-zation, 2021.
[4]	Xie YL, Chakravorty S, Armstrong DT, et al. Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis. N Engl J Med, 2017, 377(11): 1043-1054. doi:10.1056/NEJMoa1614915.
[5]	Shendure J, Ji H. Next-generation DNA sequencing. Nat Biotechnol, 2008, 26(10): 1135-1145. doi:10.1038/nbt1486. pmid: 18846087
[6]	Goig GA, Torres-Puente M, Mariner-Llicer C, et al. Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics. Bioinformatics, 2020, 36(4):985-989. doi:10.1093/bioinformatics/btz729. pmid: 31580405
[7]	Van Deun A, Wright A, Zignol M, et al. Drug susceptibility testing proficiency in the network of supranational tuberculosis reference laboratories. Int J Tuberc Lung Dis, 2011, 15(1): 116-124. pmid: 21276307
[8]	World Health Organization. Optimized broth microdilution plate methodology for drug susceptibility testing of Mycobacterium tuberculosis complex. Geneva: Word Health Organization, 2022.
[9]	Xu J, Wang B, Hu M, et al. Primary Clofazimine and Beda-quiline Resistance among Isolates from Patients with Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother, 2017, 61(6): e00239-17. doi:10.1128/AAC.00239-17.
[10]	Kaniga K, Aono A, Borroni E, et al. Validation of Bedaquiline Phenotypic Drug Susceptibility Testing Methods and Breakpoints: a Multilaboratory, Multicountry Study. J Clin Microbiol, 2020, 58(4): e01677-19. doi:10.1128/JCM.01677-19.
[11]	Kaniga K, Hasan R, Jou R, et al. Bedaquiline Drug Resis-tance Emergence Assessment in Multidrug-Resistant Tuberculosis (MDR-TB): a 5-Year Prospective In Vitro Surveillance Study of Bedaquiline and Other Second-Line Drug Susceptibility Testing in MDR-TB Isolates. J Clin Microbiol, 2022, 60(1): e0291920. doi:10.1128/JCM.02919-20.
[12]	World Health Organization. The use of next-generation sequencing technologies for the detection of mutations associated with drug resistance in Mycobacterium tuberculosis complex: technical guide. Geneva: Word Health Organization, 2018.

[1]	中国防痨协会结核病控制专业分会, 中国防痨协会青年分会, 《中国防痨杂志》编辑委员会. 中国结核病数字服药依从性技术应用指南[J]. 中国防痨杂志, 2025, 47(4): 385-397.
[2]	罗莉, 罗林紫, 尹曲华, 周磊, 卢志斌, 丁衍, 肖阳宝. 淋巴结瘘型气管支气管结核的支气管镜下诊疗进展[J]. 中国防痨杂志, 2025, 47(4): 505-512.
[3]	中国人民解放军总医院第八医学中心结核病医学部, 《中国防痨杂志》编辑委员会, 中国医疗保健国际交流促进会, 结核病防治分会基础和临床学部. 结核性腹膜炎多学科诊疗专家共识[J]. 中国防痨杂志, 2025, 47(3): 243-257.
[4]	中国防痨协会《中国防痨杂志》编辑委员会首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所 Inspire⁃CODA研究组. 康替唑胺治疗结核病专家共识[J]. 中国防痨杂志, 2025, 47(2): 123-129.
[5]	《脊柱结核并发HIV/AIDS患者诊断及治疗专家共识》编写组, 中国防痨协会骨关节结核专业分会, 中国性病艾滋病防治协会艾滋病外科专业委员会, 中国西部骨结核联盟, 中国华北骨结核联盟. 脊柱结核并发HIV/AIDS患者诊断及治疗专家共识(第2版)[J]. 中国防痨杂志, 2025, 47(1): 1-11.
[6]	齐齐, 蔡青山, 陈园园, 周丽红, 周建英. 宏基因二代测序技术对胸内淋巴结结核的诊断价值[J]. 中国防痨杂志, 2024, 46(S1): 4-8.
[7]	王彪, 刘宇红, 孙玙贤, 张立杰, 李志丽, 舒薇. 我国结核病定点医疗机构实验室检测能力调查分析[J]. 中国防痨杂志, 2024, 46(9): 1089-1097.
[8]	李杨, 孙峰, 张文宏. 结核病短程治疗研究:回顾与展望[J]. 中国防痨杂志, 2024, 46(9): 991-997.
[9]	李志丽, 刘宇红. 《世界卫生组织结核病整合指南模块6: 结核病及其共患病-HIV》解读[J]. 中国防痨杂志, 2024, 46(8): 869-873.
[10]	田宏晶, 张彦军, 邓强, 李军杰, 杨军, 刘鑫锋, 杜建强. 基于核因子κB受体活化因子配体信号通路激活破骨细胞治疗骨结核的研究进展[J]. 中国防痨杂志, 2024, 46(8): 971-975.
[11]	傅可言, 朱邦政, 叶健. 间质性肺疾病合并结核分枝杆菌感染的研究进展[J]. 中国防痨杂志, 2024, 46(7): 823-829.
[12]	刘桂珍, 邓国防. 《结核病政策指南制订过程中发现的证据和研究缺口(第2版)》解读——结核病相关共病[J]. 中国防痨杂志, 2024, 46(6): 618-624.
[13]	中国防痨协会护理专业分会, 同济大学附属上海市肺科医院. 肺结核患者营养管理护理实践专家共识[J]. 中国防痨杂志, 2024, 46(5): 495-501.
[14]	国家呼吸内科医疗质量控制中心, 中华医学会结核病学分会, 中国防痨协会结核病控制专业分会, 中日友好医院. 综合医疗机构肺结核早期发现临床实践指南[J]. 中国防痨杂志, 2024, 46(2): 127-140.
[15]	李琦, 聂文娟, 初乃惠. 耐药肺结核短程治疗方案面临的困难与挑战[J]. 中国防痨杂志, 2024, 46(11): 1297-1302.

世界卫生组织《应用新一代靶向测序技术检测耐药结核病:快速通告,2023》解读

Interpretation of the World Health Organization's Use of targeted next-generation sequencing to detect drug-resistant tuberculosis Rapid communication, 2023

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 12

相关文章 15

编辑推荐

Metrics

本文评价

友情链接