Email Alert | RSS    帮助

中国防痨杂志 ›› 2012, Vol. 34 ›› Issue (11): 736-739.

• 论著 • 上一篇    下一篇

泰安市结核病防治院2011年痰培养阳性肺结核就诊患者的耐药状况分析

孟凡亮 刘庆福 李建之 王桂梅 吕士芹   

  1. 271000  山东省泰安市结核病防治中心结核防治科（孟凡亮、李建之、王桂梅、吕士芹），参比实验室（刘庆福）
  • 收稿日期:2012-04-26 出版日期:2012-11-10 发布日期:2013-02-06
  • 通信作者: 孟凡亮 E-mail:mengfanliang11@163.com
  • 基金资助:

    泰安市科技发展计划（20113091）

Analysis of Mycobacterium tuberculosis drug-resistance situation of sputum culture positive patients visiting Tai’an Tuberculosis Prevention and Treatment Hospital in 2011

MENG Fan-liang，LIU Qing-fu，LI Jian-zhi，WANG Gui-mei，LV Shi-qin   

  1. Department of Tuberculosis Prevention and Control，Tai’an Center for Tuberculosis Prevention and Control, Shandong Province, Tai’an 271000, China
  • Received:2012-04-26 Online:2012-11-10 Published:2013-02-06
  • Contact: MENG Fan-liang E-mail:mengfanliang11@163.com

PDF (PC)

438

摘要： 目的  分析泰安市结核病防治院痰培养阳性肺结核就诊患者的耐药状况。 方法  就2011年1月至12月在泰安市结核病防治院就诊的233例痰培养阳性肺结核患者对S、Km、INH、RFP、EMB和PAS等6种抗结核药物的药敏情况及耐药类型进行分析。初治组患者171例，复治组患者62例，结果比较采用χ2检验，P<0.05为差异有统计学意义。 结果  233例痰培养阳性肺结核患者的耐药率为52.36%（122/233），其中初治痰培养阳性患者耐药率为51.46％(88/171)；复治痰培养阳性患者耐药率为54.84％(34/62)。痰培养阳性肺结核患者对一线抗结核药物耐药率较高，INH耐药率最高（30.04%，70/233），其次是S（24.46%,57/233）、EMB（23.18%,54/233）和RFP（16.74%,39/233）。耐药类型中，主要是多耐药结核病（50.00%，61/122），其次是单耐药结核病（28.69%,35/122）和MDR-TB（21.31%,26/122）。233例患者的MDR-TB耐药率为11.16％（26/233），复治患者中MDR-TB的耐药率（19.35%，12/62）高于初治组（8.19%,14/171），差异有统计学意义（χ2=5.724，P<0.05）；用过抗结核药的初治患者中MDR-TB的耐药率（23.08%,6/26）高于未用抗结核药的初治患者（5.52%,8/145），差异有统计学意义（χ2=6.699，P<0.05）。 结论  泰安市结核病防治院就诊的痰培养阳性的肺结核患者总体耐药率及INH、S、EMB和RFP的耐药率较高；复治患者和曾用过抗结核药的初治患者更容易发生MDR-TB。

关键词: 结核,肺, 分枝杆菌, 结核, 抗药性, 细菌, 泰安市

Abstract: Objective  To analyze the Mycobacterium tuberculosis drug-resistance situation of sputum culture positive patients visiting Tai’an TB Prevention and Treatment Hospital.   Methods  From January 2011 to December 2011,  a total of 233 sputum culture positive patients visited Tai’an TB Prevention and Treatment Hospital, we analyzed their drug susceptibility situation for 6 kinds of anti-TB drugs, namely S, Km, INH, RFP, EMB and PAS and their resistance pattern. According to the treatment history, patients were divided into new patients group (171 cases) and retreatment group (62 cases). Chi-square test was used to analyze if the difference is statistically significant (P<0.05).   Results  The overall drug-resistant rate of 233 sputum culture patients was 52.36% (122/233), with 51.46% (88/171) in new patients and 54.84% (34/62) in retreatment patients. Sputum culture positive patients had high drug susceptibility rate to first line drugs, with the highest of INH (30.04%,70/233), followed by S (24.46%,57/233), EMB (23.18%,54/233) and RFP(16.74%,39/233). In terms of resistance pattern, the majority was multi-drug resistant  TB (50.00% 61/122), followed by single-drug resistant  TB (28.69%,35/122) and multi-drug resistant (MDR) TB (21.31%,26/122). The overall MDR-TB rate was 11.16% (26/233), with 19.35%(12/62) in new patients and 8.19%(14/171) in new patients, the difference between two groups is statistically significant(χ2=5.724，P<0.05). The MDR-TB rate (23.08%,6/26) in patients ever used anti-TB drugs was higher than those never taken anti-TB drugs before (5.52%,8/145), and the difference is statistically significant(χ2=6.699，P<0.05). Conclusion  The overall drug-resistance rate of Mycobacterium tuberculosis and INH, S, EMB, RFP drug-resistance rates are high in sputum culturepositive patients visiting Tai’an TB Prevention and Treatment Hospital, and the retreatment and new patients who had taken anti-TB drugs before are more likely to develop MDR-TB.

Key words: Tuberculosis, pulmonary, Mycobacterium tuberculosis, Drug resistance, bacterial, Taian city

版权所有 © 2021 中国防痨协会　　　京ICP备11029069号-1   京公网安备11010202007215号
ip访问总数:  ip当日访问总数:  当前在线人数:
本作品遵循Creative Commons Attribution 3.0 License授权许可