2000—2025年老年结核病研究的全球发展趋势与研究热点:基于文献计量学的可视化分析

doi:10.19982/j.issn.1000-6621.20250202

中国防痨杂志 ›› 2025, Vol. 47 ›› Issue (10): 1365-1377.doi: 10.19982/j.issn.1000-6621.20250202

2000—2025年老年结核病研究的全球发展趋势与研究热点:基于文献计量学的可视化分析

王航星¹, 张宁², 刘晓清¹^,³^,⁴(), 康琳²()

¹中国医学科学院北京协和医院内科感染科,疑难重症及罕见病国家重点实验室,北京 100730
²中国医学科学院北京协和医院老年医学科,北京 100730
³中国医学科学院北京协和医学院临床流行病学教研室,国际临床流行病学网,北京 100730
⁴中国医学科学院北京协和医学院结核病研究中心,北京 100730

收稿日期:2025-05-16 出版日期:2025-10-10 发布日期:2025-09-29
通信作者: 刘晓清,Email:liuxqpumch@vip.163.com;康琳,Email:kangl@pumch.cn
作者简介:注:王航星和张宁对本文有同等贡献,为并列第一作者
基金资助:
中央高水平医院临床科研专项(2022-PUMCHB129);北京协和医学基金会陈志潜健康研究与决策项目

Global development trends and hotspots of researches on elderly tuberculosis, 2000—2025: a visualized bibliometric analysis

Wang Hangxing¹, Zhang Ning², Liu Xiaoqing¹^,³^,⁴(), Kang Lin²()

¹Division of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
²Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
³Clinical Epidemiology Unit, International Epidemiology Network, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
⁴Centre for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Received:2025-05-16 Online:2025-10-10 Published:2025-09-29
Contact: Liu Xiaoqing, Email:liuxqpumch@vip.163.com;Kang Lin, Email:kangl@pumch.cn
Supported by:
National High-level Hospital Clinical Research Special Fund(2022-PUMCHB129);C.C. Chen Health Research and Decision-making Project of Peking Union Medical Foundation

摘要/Abstract

摘要：

目的: 运用文献计量学方法分析2000—2025年老年结核病研究的全球发展趋势与研究热点,为今后老年结核病的研究与防控策略提供参考。方法: 以“tuberculosis”和“elderly”等为主题词,在Web of Science核心合集数据库检索2000年1月1日至2025年3月10日发表的相关文献,共检索到相关文献4103篇,限定类型为Article和Review。使用VOSviewer 1.6.18、CiteSpace 6.1.R6及Bibliometrix软件,对发文量、国家/地区与机构分布、作者、期刊及关键词进行可视化分析,并结合突现词识别研究热点与前沿。结果: 2000—2025年老年结核病研究年发文量由2000年的50篇增至2024年的350篇,呈持续增长趋势,年均复合增长率约为8.9%。发文涉及167个国家/地区和1442种期刊。发文量居前的国家为美国(996篇)、中国(598篇)、英国(400篇)、南非(332篇)和印度(319篇),合计占总量的64.3%。高产机构包括伦敦卫生与热带医学院(94篇)、开普敦大学(91篇)及威特沃特斯兰德大学(80篇)。关键词共现分析显示,研究热点集中于老年结核病流行病学特征、HIV合并感染与免疫衰老机制、诊断技术及治疗优化,其中“免疫衰老”为近年突现研究前沿。结论: 老年结核病研究持续活跃,但国际合作与交叉领域融合有待加强。应聚焦免疫衰老机制、快速诊断技术与个体化防控策略,以提升老年结核病的防治水平。

关键词: 分枝杆菌,结核, 老年人, 文献计量学, 期刊论文

Abstract:

Objective: To analyze global development trends and hotspots of researches on elderly tuberculosis from 2000 to 2025 using bibliometric methods, aiming to provide references for future research and prevention strategies. Methods: Literature with topics of “tuberculosis” and “elderly” published between January 1, 2000, and March 10, 2025, was retrieved from the Web of Science Core Collection. A total of 4103 publications were identified, limited to “Article” and “Review” categories. VOSviewer 1.6.18, CiteSpace 6.1.R6, and Bibliometrix were applied to visualize publication output, distributions of country/region and institution, authors, journals, and keywords. Research hotspots and frontiers were further identified through burst keyword detection. Results: The annual number of publications on elderly tuberculosis increased from 50 in 2000 to 350 in 2024, showing a continuous upward trend, with an average annual growth rate of approximately 8.9%. The publications involved 167 countries/regions and 1442 journals. The top five productive countries were the United States (996), China (598), the United Kingdom (400), South Africa (332), and India (319), accounting for 64.3% of the total output. Highly productive institutions included the London School of Hygiene & Tropical Medicine (94), the University of Cape Town (91), and the University of the Witwatersrand (80). Keyword co-occurrence analysis revealed that research hotspots focused on the epidemiological characteristics of elderly tuberculosis, HIV co-infection and immunosenescence mechanisms, diagnostic technologies, and treatment optimization, with “immunosenescence” emerging as a recent research frontier. Conclusion: Research on elderly tuberculosis has remained active, but international collaboration and cross-disciplinary integration require further strengthening. Future studies should focus on immunosenescence mechanisms, rapid diagnostic techniques, and individualized prevention strategies to improve tuberculosis control among the elderly.

Key words: Mycobacterium tuberculosis, Aged, Bibliometrics, Journal article

中图分类号:

R52
R592

王航星, 张宁, 刘晓清, 康琳. 2000—2025年老年结核病研究的全球发展趋势与研究热点:基于文献计量学的可视化分析[J]. 中国防痨杂志, 2025, 47(10): 1365-1377. doi: 10.19982/j.issn.1000-6621.20250202

Wang Hangxing, Zhang Ning, Liu Xiaoqing, Kang Lin. Global development trends and hotspots of researches on elderly tuberculosis, 2000—2025: a visualized bibliometric analysis[J]. Chinese Journal of Antituberculosis, 2025, 47(10): 1365-1377. doi: 10.19982/j.issn.1000-6621.20250202

图/表 14

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老年结核病研究领域被引频次最高的前10篇文献

第一作者及文献出处	标题	期刊	年份	总被引次数	年均总被引频次
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators^[20]	Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990—2017: A systematic analysis for the Global Burden of Disease Study 2017	Lancet	2018	6470	808.75
GBD 2017 Causes of Death Collaborators^[21]	Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980—2017: A systematic analysis for the Global Burden of Disease Study 2017	Lancet	2018	3112	389.00
GBD 2016 Causes of Death Collaborators^[22]	Global, regional, and national age-sex specific mortality for 264 causes of death, 1980—2016: A systematic analysis for the Global Burden of Disease Study 2016	Lancet	2017	2493	277.00
GBD 2016 Alcohol Collaborators^[23]	Alcohol use and burden for 195 countries and territories, 1990—2016: a systematic analysis for the Global Burden of Disease Study 2016	Lancet	2018	2045	255.63
Ytterberg^[24]	Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis	N Engl J Med	2022	942	235.50
Krokstad^[25]	Cohort Profile: the HUNT Study, Norway	Int J Epidemiol	2013	862	66.31
Menzies^[26]	Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research	Ann Intern Med	2007	810	42.63
Saukkonen^[27]	An official ATS statement: hepatotoxicity of antituberculosis therapy	Am J Respir Crit Care Med	2006	788	39.40
Rajpurkar^[28]	Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists	PLoS Med	2018	699	87.38
Mangtani^[29]	Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials	Clin Infect Dis	2014	663	55.25

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排名	机构名称	发文量	构成比(%)
1	伦敦卫生与热带医学院	94	2.29
2	开普敦大学	91	2.22
3	威特沃特斯兰德大学	80	1.95
4	各国卫生部^a	64	1.56
5	约翰斯·霍普金斯大学	59	1.44
6	斯泰伦博斯大学	58	1.41
7	伦敦大学学院	57	1.39
8	美国疾病控制与预防中心	56	1.36
9	加州大学旧金山分校	48	1.17
10	哈佛医学院	47	1.15
11	中国疾病预防控制中心	45	1.10
12	夸祖鲁-纳塔尔大学	45	1.07
13	麦吉尔大学	44	1.05
14	首都医科大学	43	1.05
15	马凯雷雷大学	43	1.05
16	华盛顿大学	43	1.05
17	世界卫生组织(WHO)	40	0.97
18	中国台湾大学	39	0.95
19	伦敦帝国学院	38	0.93
20	英属哥伦比亚大学	36	0.88

排序	期刊	发文量	国家	2023年影响因子(IF)	2022年 JCR分区
1	PLoS One	215	美国	2.9	Q1
2	International Journal of Tuberculosis and Lung Disease	166	法国	3.8	Q2
3	BMC Infectious Diseases	105	英国	3.4	Q2
4	BMC Public Health	56	英国	3.5	Q1
5	Clinical Infectious Diseases	54	美国	8.2	Q1
6	Cureus	45	美国	1.0	Q3
7	Scientific Reports	44	英国	3.8	Q1
8	Frontiers in Public Health	39	瑞士	3.0	Q2
9	BMJ Open	37	英国	2.4	Q1
10	Medicine (Baltimore)	34	美国	1.4	Q2

2000—2025年老年结核病研究的全球发展趋势与研究热点:基于文献计量学的可视化分析

Global development trends and hotspots of researches on elderly tuberculosis, 2000—2025: a visualized bibliometric analysis

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参考文献 41

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排序	作者	发文量	H指数
1	Turner J	25	14
2	Wang W	19	8
3	Zhang H	18	11
4	Chen B	17	6
5	Seddon JA	16	10
6	Torrelles JB	16	8
7	Wang JY	16	10
8	Zar HJ	16	10
9	Chen W	15	8
10	Kang YA	15	6

排序	关键词	频次
1	tuberculosis	1056
2	aging	313
3	HIV	184
4	epidemiology	139
5	mortality	134
6	risk factor	129
7	pulmonary tuberculosis	118
8	Mycobacterium tuberculosis	94
9	children	87
10	diabetes	73

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