Research progress on recombinant protein subunit vaccine of tuberculosis

doi:10.3969/j.issn.1000-6621.2021.09.019

Abstract

Abstract:

Bacille Calmette-Guérin (BCG) is the only tuberculosis vaccine used clinically, but its protective effect against adult tuberculosis is still uncertain. Recombinant protein subunit vaccines can provide long-term immune protection, and have clear ingredients and good safety, so they have good prospects of application development. This article reviews the progress of the components of the tuberculosis recombinant protein subunit vaccine, including the protective antigens and adjuvants of Mycobacterium tuberculosis, the current status of clinical research, the application strategies and challenges faced by the research.

Key words: Mycobacterium tuberculosis, Vaccines,subunit, Recombinant proteins, Review literature as topic

CAO Qian-qian, ZHU Bing-dong, NIU Hong-xia. Research progress on recombinant protein subunit vaccine of tuberculosis[J]. Chinese Journal of Antituberculosis, 2021, 43(9): 970-974. doi: 10.3969/j.issn.1000-6621.2021.09.019

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