Chinese Journal of Antituberculosis ›› 2021, Vol. 43 ›› Issue (9): 916-923.doi: 10.3969/j.issn.1000-6621.2021.09.011
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ZHAO Xiu-juan, MO Jing-lian, SUN Tao, LIU Lin, ZHONG Ye-teng, PEI Hua(), XIA Qian-feng()
Received:
2021-04-02
Online:
2021-09-10
Published:
2021-09-07
Contact:
PEI Hua,XIA Qian-feng
E-mail:phzmh61@aliyun.com;xiaqianfeng@hainmc.edu.cn
ZHAO Xiu-juan, MO Jing-lian, SUN Tao, LIU Lin, ZHONG Ye-teng, PEI Hua, XIA Qian-feng. Prevalence and correlated factors of drug-resistant pulmonary tuberculosis admitted to the designated medical institutions in Hainan Province from 2015 to 2019[J]. Chinese Journal of Antituberculosis, 2021, 43(9): 916-923. doi: 10.3969/j.issn.1000-6621.2021.09.011
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特征 | 例数 | 构成比(%) | ||
---|---|---|---|---|
性别 | ||||
男性 | 1013 | 82.42 | ||
女性 | 216 | 17.58 | ||
年龄(岁) | ||||
0~19 | 51 | 4.15 | ||
20~39 | 325 | 26.45 | ||
40~59 | 492 | 40.03 | ||
60~95 | 361 | 29.37 | ||
治疗分类 | ||||
初治 | 652 | 53.05 | ||
复治 | 577 | 46.95 | ||
民族 | ||||
汉族 | 1147 | 93.33 | ||
少数民族 | 82 | 6.67 | ||
婚姻a | ||||
已婚 | 971 | 79.01 | ||
未婚 | 258 | 20.99 | ||
特征 | 例数 | 构成比(%) | ||
职业b | ||||
非体力劳动者 | 428 | 34.83 | ||
体力劳动者 | 801 | 65.17 | ||
家族史c | ||||
否认 | 1127 | 91.70 | ||
有 | 102 | 8.30 | ||
接触史 | ||||
否认 | 1075 | 87.47 | ||
有 | 154 | 12.53 | ||
吸毒史 | ||||
否认 | 1210 | 98.45 | ||
有 | 19 | 1.55 | ||
吸烟史 | ||||
否认 | 620 | 50.45 | ||
有 | 609 | 49.55 | ||
饮酒史 | ||||
否认 | 942 | 76.65 | ||
有 | 287 | 23.35 | ||
糖尿病 | ||||
无 | 949 | 77.22 | ||
有 | 280 | 22.78 | ||
高血压 | ||||
无 | 1139 | 92.68 | ||
有 | 90 | 7.32 | ||
冠心病 | ||||
无 | 1204 | 97.97 | ||
有 | 25 | 2.03 | ||
慢性阻塞性肺疾病 | ||||
无 | 1171 | 95.28 | ||
有 | 58 | 4.72 | ||
药物性肝损伤 | ||||
无 | 1102 | 89.67 | ||
有 | 127 | 10.33 | ||
高尿酸血症 | ||||
无 | 1102 | 89.67 | ||
有 | 127 | 10.33 | ||
肺癌 | ||||
无 | 1193 | 97.07 | ||
有 | 36 | 2.93 | ||
呼吸衰竭 | ||||
无 | 1177 | 95.77 | ||
有 | 52 | 4.23 | ||
空洞 | ||||
无 | 797 | 64.85 | ||
有 | 432 | 35.15 |
药物敏感性 | 初治(652例) | 复治(577例) | 合计(1229例) | χ2值 | P值 | |||
---|---|---|---|---|---|---|---|---|
例数 | 百分率 (%) | 例数 | 百分率 (%) | 例数 | 百分率 (%) | |||
敏感 | 515 | 78.99 | 202 | 35.01 | 717 | 58.34 | 243.600 | <0.001 |
任一耐药 | ||||||||
RFP | 65 | 9.97 | 329 | 57.02 | 394 | 32.06 | 311.105 | <0.001 |
INH | 86 | 13.19 | 301 | 52.17 | 387 | 31.49 | 215.552 | <0.001 |
Sm | 71 | 10.89 | 190 | 32.93 | 261 | 21.24 | 88.891 | <0.001 |
EMB | 18 | 2.76 | 104 | 18.02 | 122 | 9.93 | 79.759 | <0.001 |
耐多药 | ||||||||
INH+RFP | 12 | 1.84 | 85 | 14.73 | 97 | 7.89 | 69.972 | <0.001 |
INH+RFP+Sm | 16 | 2.45 | 85 | 14.73 | 101 | 8.22 | 61.173 | <0.001 |
INH+RFP+EMB | 12 | 1.84 | 28 | 4.85 | 40 | 3.25 | 8.821 | 0.003 |
INH+RFP+Sm+EMB | 6 | 0.92 | 66 | 11.44 | 72 | 5.86 | 61.404 | <0.001 |
多耐药 | ||||||||
INH+Sm | 16 | 2.45 | 11 | 1.91 | 27 | 2.20 | 0.427 | 0.513 |
RFP+Sm | 1 | 0.15 | 14 | 2.43 | 15 | 1.22 | 13.118 | <0.001 |
RFP+EMB | 0 | 0.00 | 3 | 0.52 | 3 | 0.24 | -a | 0.103a |
INH+Sm+EMB | 0 | 0.00 | 4 | 0.69 | 4 | 0.33 | -a | 0.048a |
RFP+Sm+EMB | 0 | 0.00 | 2 | 0.35 | 2 | 0.16 | -a | 0.220a |
年份 | 总例数 | 初治 例数 | 复治 例数 | 耐药[例,率(%)] | 耐多药[例,率(%)] | ||||
---|---|---|---|---|---|---|---|---|---|
初治 | 复治 | 合计 | 初治 | 复治 | 合计 | ||||
2015 | 170 | 85 | 85 | 20(23.53) | 62(72.94) | 82(48.24) | 4(4.71) | 46(54.12) | 50(29.41) |
2016 | 105 | 33 | 72 | 6(18.18) | 46(63.89) | 52(49.52) | 1(3.03) | 35(48.61) | 36(34.29) |
2017 | 186 | 84 | 102 | 21(25.00) | 67(65.69) | 88(47.31) | 6(7.14) | 46(45.10) | 52(27.96) |
2018 | 323 | 182 | 141 | 36(19.78) | 80(56.74) | 116(35.91) | 10(5.49) | 51(36.17) | 61(18.89) |
2019 | 445 | 268 | 177 | 54(20.15) | 120(67.80) | 174(39.10) | 25(9.33) | 86(48.59) | 111(24.94) |
合计 | 1229 | 652 | 577 | 137(21.01) | 375(64.99) | 512(41.66) | 46(7.06) | 264(45.75) | 310(25.22) |
因素 | 对照组(279例) | 观察组(279例) | 合计 | χ2值 | P值 |
---|---|---|---|---|---|
治疗分类 | 77.400 | <0.001 | |||
初治 | 192(68.82) | 41(14.70) | 233(41.76) | ||
复治 | 87(31.18) | 238(85.30) | 325(58.24) | ||
民族 | 3.203 | 0.074 | |||
汉族 | 268(96.06) | 258(92.47) | 526(94.27) | ||
少数民族 | 11(3.94) | 21(7.53) | 32(5.73) | ||
婚姻a | 0.061 | 0.806 | |||
已婚 | 223(79.93) | 221(79.21) | 444(79.57) | ||
未婚 | 56(20.07) | 58(20.79) | 114(20.43) | ||
职业b | 1.139 | 0.286 | |||
非体力劳动者 | 98(35.13) | 86(30.82) | 184(32.97) | ||
体力劳动者 | 181(64.87) | 193(69.18) | 374(67.03) | ||
家族史c | 0.508 | 0.476 | |||
否认 | 256(91.76) | 251(89.96) | 507(90.86) | ||
有 | 23(8.24) | 28(10.04) | 51(9.14) | ||
接触史 | 0.937 | 0.333 | |||
否认 | 245(87.81) | 237(84.95) | 482(86.38) | ||
有 | 34(12.19) | 42(15.05) | 76(13.62) | ||
吸毒史 | 2.099 | 0.147 | |||
否认 | 275(98.57) | 270(96.77) | 545(97.67) | ||
有 | 4(1.43) | 9(3.23) | 13(2.33) | ||
吸烟史 | 1.031 | 0.310 | |||
否认 | 134(48.03) | 145(51.97) | 279(50.00) | ||
有 | 145(51.97) | 134(48.03) | 279(50.00) | ||
因素 | 对照组(279例) | 观察组(279例) | 合计 | χ2值 | P值 |
饮酒史 | 5.807 | 0.016 | |||
否认 | 203(72.76) | 226(81.00) | 429(76.88) | ||
有 | 76(27.24) | 53(19.00) | 129(23.12) | ||
糖尿病 | 2.349 | 0.125 | |||
无 | 222(79.57) | 207(74.19) | 429(76.88) | ||
有 | 57(20.43) | 72(25.81) | 129(23.12) | ||
高血压 | 4.523 | 0.033 | |||
无 | 258(92.47) | 270(96.77) | 528(94.62) | ||
有 | 21(7.53) | 9(3.23) | 30(5.38) | ||
冠心病 | 0.111 | 0.739 | |||
无 | 275(98.57) | 274(98.21) | 549(98.39) | ||
有 | 4(1.43) | 5(1.79) | 9(1.61) | ||
慢性阻塞性肺疾病 | 1.426 | 0.232 | |||
无 | 271(97.13) | 266(95.34) | 537(96.24) | ||
有 | 8(2.87) | 13(4.66) | 21(3.76) | ||
药物性肝损伤 | 8.700 | 0.003 | |||
无 | 240(86.02) | 262(93.91) | 502(89.96) | ||
有 | 39(13.98) | 17(6.09) | 56(10.04) | ||
高尿酸血症 | 3.977 | 0.046 | |||
无 | 262(93.91) | 249(89.25) | 511(91.58) | ||
有 | 17(6.09) | 30(10.75) | 47(8.42) | ||
肺癌 | 3.906 | 0.048 | |||
无 | 265(94.98) | 274(98.21) | 539(96.59) | ||
有 | 14(5.02) | 5(1.79) | 19(3.41) | ||
呼吸衰竭 | 0.874 | 0.350 | |||
无 | 272(97.49) | 268(96.06) | 540(96.77) | ||
有 | 7(2.51) | 11(3.94) | 18(3.23) | ||
空洞 | 16.814 | <0.001 | |||
无 | 97(34.77) | 54(19.35) | 151(27.06) | ||
有 | 182(65.23) | 225(80.65) | 407(72.94) |
影响因素 | β值 | s | Wald χ2值 | P值 | OR (95%CI)值 |
---|---|---|---|---|---|
治疗分类 | |||||
初治 | 1.000 | ||||
复治 | 2.510 | 0.304 | 68.073 | <0.001 | 12.305(6.778~22.337) |
饮酒史 | |||||
否认 | 1.000 | ||||
有 | -0.576 | 0.324 | 3.160 | 0.075 | 0.562(0.298~1.061) |
高血压 | |||||
无 | 1.000 | ||||
有 | -0.348 | 0.540 | 0.415 | 0.520 | 0.706(0.245~2.034) |
药物性肝损伤 | |||||
无 | 1.000 | ||||
有 | -0.191 | 0.432 | 0.196 | 0.658 | 0.826(0.354~1.926) |
高尿酸血症 | |||||
无 | 1.000 | ||||
有 | 1.001 | 0.479 | 4.367 | 0.037 | 2.720(1.064~6.951) |
肺癌 | |||||
无 | 1.000 | ||||
有 | -0.755 | 0.719 | 1.103 | 0.294 | 0.470(0.115~1.923) |
空洞 | |||||
无 | 1.000 | ||||
有 | 0.702 | 0.290 | 5.860 | 0.015 | 2.017(1.143~3.560) |
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