The tuberculosis drug-resistance and transmission surveillance network based on whole genome sequencing data

doi:10.3969/j.issn.1000-6621.2021.07.001

Abstract

Abstract:

The surveillance of tuberculosis drug-resistance and transmission provide important information to making up public health policies. Whole genome sequencing (WGS) of Mycobacterium tuberculosis (MTB) has an advantage over the traditional phenotypic drug susceptibility test and genotyping in drug resistance detection and transmission identification, and has been introduced into the health system of some developed countries. The establishment of the WGS data analysis platform, SAM-TB, makes it possible to construct a national tuberculosis drug-resistance and transmission surveillance database base on MTB WGS data. The authors suggest that this work should be carried out step by step at the provincial level, and finally a nationwide surveillance network of tuberculosis drug resistance and transmission can be formed.

Key words: Mycobacterium tuberculosis, Genome, bacterial, Sequence analysis, DNA, Drug resistance, bacterial, Population surveillance

YANG Ting-ting, GAO Qian. The tuberculosis drug-resistance and transmission surveillance network based on whole genome sequencing data[J]. Chinese Journal of Antituberculosis, 2021, 43(7): 645-648. doi: 10.3969/j.issn.1000-6621.2021.07.001

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